Nivolumab Improves Clinical Outcomes in Patients With Relapsed-Refractory Hodgkin Lymphoma After ASCT, Brentuximab Vedotin

Share this content:
Nivolumab produced high response rates when administered to patients with R-R Hodgkin lymphoma following ASCT.
Nivolumab produced high response rates when administered to patients with R-R Hodgkin lymphoma following ASCT.

Regardless of previous history with brentuximab vedotin, patients with classic relapsed/refractory Hodgkin lymphoma (R/R HL) following autologous stem cell transplantation (ASCT) who received nivolumab experienced high rates of response. Complete response (CR) and partial response (PR) seemed durable on continued follow-up, according to the results from the phase 2 CheckMate 205 trial ( identifier: NCT02181738) presented at the 14th Annual Conference on Malignant Lymphoma.

Nivolumab (Opdivo®) is a monoclonal antibody that inhibits programmed cell death-1 and is indicated in patients with R/R HL after ASCT and brentuximab vedotin. Patients with R/R HL face a dearth of treatment options following ASCT. The extended follow-up results from CheckMate 205 describe clinical outcomes in all patients with R/R HL after failure of ASCT.

Continue Reading Below

Cohort A included 63 patients who were treatment-naïve for brentuximab vedotin; Cohort B, 80 patients who received brentuximab vedotin after ASCT; and Cohort C, 100 patients who received brentuximab vedotin before (n=33), after (n=58), and before and after (n=9) ASCT.

All patients received 3 mg/kg of nivolumab once every 2 weeks until progression or unacceptable toxicity. Patients in Cohort C who experienced CR for 1 year discontinued nivolumab and could restart nivolumab on relapse.

Patient age ranged from 18 years to 72 years (median: 34 years), and more than three-quarters of patients had stage III or greater disease on entry into the study. Median follow-up was 19 months in Cohort A, 23 months in Cohort B, and 16 months in Cohort C, at which point 40% of patients remained on treatment.

Overall response rate was 65% in brentuximab vedotin-naïve patients (Cohort A), 68% in patients with brentuximab vedotin after ASCT (Cohort B), and 73% in patients with brentuximab vedotin before and/or after ASCT (Cohort C). CR was 29% in Cohort A, 13% in Cohort B, and 12% in Cohort C.

Median duration of response (DOR) was 20 months in brentuximab vedotin-naïve patients. In patients who received brentuximab vedotin, median DOR was 16 months (Cohort B) and 15 months (Cohort C).

In patients with CR, DOR was 20 months in Cohort A and 15 months or longer in Cohorts B and C. Median OS was not reached.

The most frequent treatment-related adverse events (TRAEs) were fatigue (23%), diarrhea (15%), and infusion reactions (14%). The most frequent serious TRAEs were infusion reactions (2%) and pneumonitis (1%).


1. Fanale M, Engert A, Younes A, et al. Nivolumab for relapsed/refractory classical Hodgkin lymphoma after autologous transplant: full results after extended follow-up of the phase 2 CheckMate 205 trial. Oral presentation at: 14th International Conference on Malignant Lymphoma; June 14-17, 2017; Lugano, Switzerland.

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs