Radiation-Induced Esophagitis: A Common, Debilitating Clinical Challenge in Thoracic Radiotherapy

A review of current options and ongoing trials for managing ARIE, a common esophageal adverse effect caused by radiotherapy to the thoracic region for lung, breast, or head and neck cancers, or lymphoma.

Ado-trastuzumab Emtansine Effective in HER2 Amplified Non-breast, Non-gastric Cancers

Study results presented at 2018 ASCO Annual Meeting demonstrated effectiveness of ado-trastuzumab emtansine in non-breast non-gastric HER2-amplified cancers.

Response to Rapamycin Analogs but not PD-1 Inhibitors in PTEN-mutated Metastatic Non-small Cell Lung Cancer With High Tumor Mutational Burden

[Lung Cancer: Targets and Therapy] This case study demonstrates that genomic profiling may still benefit patients who fail checkpoint inhibitor therapy despite having high tumor mutational burden and PD-L1 positivity.

Lung Cancer Incidence is Higher for Young Women Than Young Men

Researchers observed a decrease in the age-specific incidence of lung cancer among both men and women aged 30 to 54 years over the past two decades; the declines among men were steeper.

Multiple Treatment Modalities for Brain Metastasis in Patients With EGFR-mutant Non-small Cell Lung Cancer

[OncoTargets and Therapy] Management of brain metastases in patients with EGFR-mutant NSCLC is controversial. In this study, researchers find combination and sequential treatment with EGFR-TKIs, chemotherapy, and radiotherapy is beneficial.

Lung Cancer Screening Program In Ambulatory Clinics May Improve Detection Rates

A study presented at the 2018 ONS Annual Congress explored the feasibility of an advanced practice nurse-led lung cancer screening program at ambulatory outpatient clinics.

Role and Inhibition of GLI1 Protein in Cancer

[Lung Cancer: Targets and Therapy] Italian researchers report on the role of GLI1 in the development of lung cancer, and review its potential as an effective therapy for lung cancer.

Proteomic Biomarker Sensitive, Specific in Distinguishing Benign From Malignant Lung Nodules

The integrated proteomic classifier performed better than positron emission tomography, validated lung nodule risk models, and physician cancer probability estimates.

Clinical Trial: Improving Management of Breathlessness in Patients With Lung Cancer

Clinical Trial: Lung Cancer Screening Study With Low-dose CT Scan and Blood Biomarker

Clinical Trial: Lung Cancer Biomarkers and Screening (NYULCBC)