Survival Predictions for NSCLC Accurate With the Lung Cancer Prognostic Index

Share this content:
LCPI may be useful for guiding clinical trial eligibility.
LCPI may be useful for guiding clinical trial eligibility.

The Lung Cancer Prognostic Index (LCPI) provides additional relevant prognostic data for patients with non-small cell lung cancer (NSCLC) and may lead to better outcomes, according to a study published in the British Journal of Cancer.

There are numerous prognostic models for patients with NSCLC, but their ability to provide accurate prognoses is limited as they are primarily dictated by staging. Staging plays an important role in determining therapy and predicting outcomes, but the heterogeneity even within stage groups of NSCLC suggests there are variable factors that affect prognosis in this patient population. 

Continue Reading Below

The study enrolled 695 patients with newly diagnosed NSCLC to derive the LCPI, and tested the index in 2 independent validation cohorts involving 763 patients.  

The variables that had significant associations with overall survival (OS) assessed in the LCPI included stage, mutation status, histology, performance status, smoking history, respiratory comorbidity, weight loss, sex, and age.

According to the LCPI, the 2-year OS rates in the derivation cohort and two validation cohorts were respectively 84%, 77%, and 68% (LCPI 1 score ≤ 9); 61%, 61%, and 42% (LCPI2 score 10-13); 33%, 32%, and 14% (LCPI 3 score 14-16); 7%, 16%, and 5% (LCPI 4 score > 15).

The study shows that LCPI is a simple and generalizable scoring system, which may have utility in guiding trial eligibility or design, counseling patients, or standardizing mortality risk for epidemiological risk.


1. Marliese A, Wolfe R, Ball D, et al. Lung cancer prognostic index: a risk score to predict overall survival after the diagnosis of non-small-cell lung cancer [published online July 20, 2017]. Br J Cancer. doi: 10.1038/bjc.2017.232

You must be a registered member of ONA to post a comment.

Sign Up for Free e-newsletters

Regimen and Drug Listings


Bone Cancer Regimens Drugs
Brain Cancer Regimens Drugs
Breast Cancer Regimens Drugs
Endocrine Cancer Regimens Drugs
Gastrointestinal Cancer Regimens Drugs
Genitourinary Cancer Regimens Drugs
Gynecologic Cancer Regimens Drugs
Head and Neck Cancer Regimens Drugs
Hematologic Cancer Regimens Drugs
Lung Cancer Regimens Drugs
Other Cancers Regimens
Rare Cancers Regimens
Skin Cancer Regimens Drugs