CPI-613 safe and somewhat efficacious for patients with leukemia
the ONA take:
According to a new study published in the journal Clinical Cancer Research, a phase 1 study has demonstrated that a novel investigational drug, known as CPI-613, was safe and somewhat efficacious for the treatment of patients with relapsed or refractory leukemia. In the study, researchers enrolled 26 patients with relapsed or refractory hematological cancers and administered CPI-613 on days 1 and 4 weekly for 3 weeks of a 28-day cycle.
Of 21 evaluable patients, 29% experienced some benefit from the treatment. One patient achieved a complete response and that patient's remission has lasted over 3 years. Another patient achieved a partial response with a remission that lasted greater than 2 years.
CPI-613 is the first drug to inhibit the production of energy in the mitochondria of cancer cells, thereby inhibiting proliferation and damage repair from chemotherapy. The drug is currently being studied in phase 2 studies in both solid tumors and hematological malignancies, and it was granted orphan drug status by the U.S. Food and Drug Administration (FDA) for pancreatic cancer. CPI-613 is being developed by Cornerstone Pharmaceuticals.
CPI-613 safe and somewhat efficacious for relapsed or refractory leukemia.
Results of a Phase I clinical trial showed that a new drug targeting mitochondrial function in human cancer cells was safe and showed some efficacy. The findings, reported by doctors at Wake Forest Baptist Medical Center, are published in the current online edition of the journal Clinical Cancer Research."
This drug is selectively taken up by cancer cells and then shuts down the production of energy in the mitochondria," said Timothy Pardee, M.D., Ph.D., director of leukemia translational research at Wake Forest Baptist and principal investigator of the trial. "This is the first drug to inhibit mitochondria in this way and if it proves effective in further clinical trials, it will open up a whole new approach to fighting cancer."
Sign Up for Free e-newsletters
- Is Radioimmunotherapy a Path Forward for Melanoma?
- FDA Approves Mogamulizumab-kpkc for Rare Subtypes of Non-Hodgkin Lymphoma
- New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab
- Intensive Chemotherapy May Not Be Effective in MDS or AML After MDS
- ASCO Endorses SIO Guideline for Integrative Therapies in Breast Cancer
- NCCIH HerbList App Launched to Provide Information on Herbal Products
- Metformin Use May Improve Survival Outcomes in Bladder Cancer
- Higher Vitamin D Levels Associated With Lower Breast Cancer Risk
- Nurse-Led Program Improves Health, Financial Outcomes in Outpatient Chemotherapy
- Seeking Reliable Information on Herbal Products
- Disparities Remain in Prevalence of Cancer Screening Tests
- Hope, Gratitude, and Spirituality: What They Mean to Cancer Patients
- FDA, EU Approvals Sought for Split Dose Regimen of Daratumumab for Multiple Myeloma
- 8 Hours of Bedrest May Be Ideal After Intrathecal Chemotherapy in Hematologic Cancers
- Combined Digital Screening Best for Detecting Breast Cancers
Regimen and Drug Listings
GET FULL LISTINGS OF TREATMENT Regimens and Drug INFORMATION
|Head and Neck Cancer||Regimens||Drugs|