Drug Name:
Idarubicin Rx
Generic Name and Formulations:
Idarubicin HCl 20mg/vial; lyophilized pwd for IV infusion after reconstitution.
Company:
Various generic manufacturers
Therapeutic Use:
Indications for Idarubicin:
Acute myeloid leukemia.
Adult:
Give by slow IV infusion (over 10–15 mins). 12mg/m2 daily for 3 days (in combination with cytarabine). May give 2nd course if needed; if toxicity develops after 1st course, delay until resolved; reduce dose by 25%. Hepatic and renal impairment: consider reduce dose.
Children:
Not established.
Warnings/Precautions:
Pre-existing bone marrow suppression. Cardiovascular disease. Thoracic irradiation. Previous anthracycline therapy at high cumulative doses. Renal or hepatic impairment. Monitor CBCs, cardiac, renal and hepatic function prior to and during treatment. Avoid extravasation. Elderly. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.
See Also:
Pharmacological Class:
Anthracycline.
Interactions:
Concomitant drugs that suppress cardiac contractility or cardiotoxic drugs (eg, trastuzumab, cyclophosphamide, paclitaxel): not recommended; avoid use for 5 half-lives after discontinuing cardiotoxic drug.
Adverse Reactions:
Myelosuppression, GI upset, mucositis, abdominal pain, alopecia, rash, inj site reactions, hepatotoxicity, renal toxicity, cardiotoxicity (eg, CHF, arrhythmias, chest pain, MI, asymptomatic declines in LVEF), hyperuricemia.
How Supplied:
Single-dose vials—contact supplier; PFS: Single-dose vials (5mL, 10mL, 20mL)—1
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