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Antiphospholipid syndrome

Antiphospholipid syndrome What every physician needs to know: Antiphospholipid (antibody) syndrome (APS) is a prothrombotic condition characterized by both of the following: Persistent presence of antiphospholipid antibodies – That is, lupus anticoagulant/non-specific inhibitor, anticardiolipin antibodies, and/or anti-ß2-glycoprotein I antibodies.Continue Reading Venous or arterial thrombosis, or pregnancy morbidity – This is defined as unexplained death greater…

Hodgkin lymphoma

Hodgkin lymphoma What every physician needs to know: Hodgkin lymphoma (HL) is divided into two subgroups, including classical HL (CHL) and nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). While classical HL is divided into four distinct entities: nodular sclerosis, mixed cellularity, lymphocyte-rich, and lymphocyte-depleted, the subtypes have little prognostic significance with current therapies. However, differentiating between…

Non-infectious complications after bone marrow transplant: other organs toxicity II

Non-infectious complications after bone marrow transplant: other organs toxicity II What every physician needs to know about non-infectious complications after bone marrow transplant: other organ toxicity II: Definition and incidence This section summarizes endocrine and central nervous system (CNS) complications of bone marrow transplantation. Endocrine system complications can be subtle and therefore difficult to diagnose;…

Non-infectious complications after bone marrow transplant: other organs toxicity I

Non-infectious complications after bone marrow transplant: other organs toxicity I What every physician needs to know about complications after bone marrow transplant: organ toxicity I This section describes and discusses genitourinary system (GUS) complications of bone marrow transplantation (BMT). These complications are very common and caused by various etiology. Herein, we also discuss microangiopathic hemolytic…

Non-infectious complications after bone marrow transplant: secondary cancer

Non-infectious complications after bone marrow transplant: secondary cancer What every physician needs to know about non-infectious complications after bone marrow transplant: secondary cancer Bone marrow transplant is carried out in order to cure a hematologic malignancy; however, by itself it can cause other cancers. Post-transplant malignancy can occur because of either relapse of primary cancer…

Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease

Non-infectious complications after bone marrow transplant: chronic graft-versus-host disease What every physician needs to know about chronic graft-versus-host disease after bone marrow transplant: Definition and incidence Chronic graft-versus-host-disease (cGVHD) is the leading cause of later non-relapse mortality and morbidity after allo-hematopoietic stem cell transplantation (HCT). CGVHD can occur following acute graft-versus-host-disease (aGVHD), can overlap with…

Non-infectious complications after bone marrow transplant: liver complications

Non-infectious complications after bone marrow transplant: liver complications What every physician needs to know about non-infectious complications after bone marrow transplant: liver complications: Liver complications of hematopoietic cell transplantation (HCT) are common and multi-factorial. We will discuss the most frequent complications. Definition Veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS) Continue Reading VOD…

Non-infectious complications after bone marrow transplant: pulmonary complications

Non-infectious complications after bone marrow transplant: pulmonary complications What every physician needs to know about non-infectious complications after bone marrow transplant: pulmonary complications: Summary Non-infectious pulmonary complications after allogeneic hematopoietic cell transplantation are common but their differential diagnoses are difficult. The purpose of this chapter is to enable the right diagnosis to be made, by…

Non-infectious complications after bone marrow transplant: acute graft-versus-host disease

Non-infectious complications after bone marrow transplant: acute graft-versus-host disease What every physician needs to know about non-infectious complications after bone marrow transplant: acute graft-versus-host disease: Acute graft-versus-host disease (aGVHD) is the most common and important complication of allogenic hematopoietic stem cell transplant (alloHCT). AGVHD is an immunologically mediated disease occurring in an immunologically compromised host…

Mechanical hemolysis

Mechanical hemolysis What every physician needs to know about mechanical hemolysis: Mechanical hemolysis is due to excessive mechanical forces that damage red blood cells (RBCs). Continue Reading Hallmark: fragmented red cells or schistocytes Schistocytes are not as flexible as normal RBCs and are cleared from the circulation by the mononuclear phagocyte system Large amounts of…

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