Use of vaccination against B pertussis has been well studied.38 The diphtheria, tetanus, and acellular pertussis (DTaP) vaccine is indicated only for children younger than 7 years of age.38 However, the adult tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is a 3-dose series with high tetanus and pertussis content that may be more immunogenic in recipients of hematopoietic stem cell transplantation, so it should be considered as the initial vaccination for this patient population, regardless of age.38 Furthermore, Suzuki et al30 suggested that acellular pertussis vaccine can be considered for patients after receiving hematopoietic stem cell transplantation, even if they are adults or older than 7 years of age.

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We presented 2 patients who had good outcomes following azithromycin treatment. Due to the advent of and availability of polymerase chain reaction–based diagnostic testing, the rate of Bordetella pertussis infection among patients who are immunocompromised and have cancer is expected to increase.39 Such testing can be easily done via a nasopharyngeal swab. The literature is scant regarding pertussis in adults — and this is particularly true among those with cancer — due to the historical difficulty of accurate diagnostic testing.39

Abraham Yacoub, MD, Sowmya Nanjappa, MD, Tyler Janz, and John N. Greene, MD 

From the Division of Infectious Diseases (AY, JNG) and Interna- tional Medicine (AY), Departments of Internal Medicine (SN) and Oncologic Sciences (SN), H. Lee Moffitt Cancer Center & Research Institute, and the Morsani College of Medicine (AY, SM, JNG), De- partment of Biomedical Sciences (TJ), University of South Florida, Tampa, Florida.

Submitted January 20, 2016; accepted March 5, 2016.

Address correspondence to John N. Greene, MD, Department of Infectious Diseases, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497. E-mail: [email protected]

No significant relationships exist between the authors and the companies/organizations whose products or services may be ref- erenced in this article. 


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Source: Cancer Control.
Originally published April, 2016.