Use of vaccination against B pertussis has been well studied.38 The diphtheria, tetanus, and acellular pertussis (DTaP) vaccine is indicated only for children younger than 7 years of age.38 However, the adult tetanus, diphtheria, and acellular pertussis (Tdap) vaccine is a 3-dose series with high tetanus and pertussis content that may be more immunogenic in recipients of hematopoietic stem cell transplantation, so it should be considered as the initial vaccination for this patient population, regardless of age.38 Furthermore, Suzuki et al30 suggested that acellular pertussis vaccine can be considered for patients after receiving hematopoietic stem cell transplantation, even if they are adults or older than 7 years of age.
We presented 2 patients who had good outcomes following azithromycin treatment. Due to the advent of and availability of polymerase chain reaction–based diagnostic testing, the rate of Bordetella pertussis infection among patients who are immunocompromised and have cancer is expected to increase.39 Such testing can be easily done via a nasopharyngeal swab. The literature is scant regarding pertussis in adults — and this is particularly true among those with cancer — due to the historical difficulty of accurate diagnostic testing.39
Abraham Yacoub, MD, Sowmya Nanjappa, MD, Tyler Janz, and John N. Greene, MD
From the Division of Infectious Diseases (AY, JNG) and Interna- tional Medicine (AY), Departments of Internal Medicine (SN) and Oncologic Sciences (SN), H. Lee Moffitt Cancer Center & Research Institute, and the Morsani College of Medicine (AY, SM, JNG), De- partment of Biomedical Sciences (TJ), University of South Florida, Tampa, Florida.
Submitted January 20, 2016; accepted March 5, 2016.
Address correspondence to John N. Greene, MD, Department of Infectious Diseases, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612-9497. E-mail: [email protected]
No significant relationships exist between the authors and the companies/organizations whose products or services may be ref- erenced in this article.
1. Oh YW, Effmann EL, Godwin JD. Pulmonary infections in immunocompromised hosts: the importance of correlating the conventional radiologic appearance with the clinical setting. Radiology. 2000;217(3):647-656.
2. Conces DJ Jr. Bacterial pneumonia in immunocompromised patients. J Thorac Imaging. 1998;13(4):261-270.
3. Hewitt M, Canning BJ. Coughing precipitated by Bordetella pertussis infection. Lung. 2010;188(suppl 1):S73-S79.
4. Ward JI, Cherry JD, Chang SJ, et al; APERT Study Group. Bordetella pertussis infections in vaccinated and unvaccinated adolescents and adults, as assessed in a national prospective randomized Acellular Pertussis Vaccine Trial (APERT). Clin Infect Dis. 2006;43(2):151-157.
5. Bloom DE. The value of vaccination. Adv Exp Med Biol. 2011;697:1-8.
6. Shumilla JA, Lacaille V, Hornell TM, et al.Bordetella pertussis infection of primary human monocytes alters HLA-DR expression. Infect Immun. 2004;72(3):1450-1462.
7. Skerry CM, Mahon BP. A live, attenuated Bordetella pertussis vaccine provides long-term protection against virulent challenge in a murine model. Clin Vaccine Immunol. 2011;18(2):187-193.
8. Greenberg D, Bamberger E, Ben-Shimol S, et al. Pertussis is under diagnosed in infants hospitalized with lower respiratory tract infection in the pediatric intensive care unit. Med Sci Monit. 2007;13(11):CR475-CR480.
9. Bettiol S, Thompson MJ, Roberts NW, et al. Symptomatic treatment of the cough in whooping cough. Cochrane Database Syst Rev. 2010;(1):CD003257.
10. Sandora TJ, Gidengil CA, Lee GM. Pertussis vaccination for health care workers. Clin Microbiol Rev. 2008;21(3):426-434.
11. Guiso N. Bordetella pertussis and pertussis vaccines. Clin Infect Dis. 2009;49(10):1565-1569.
12. Mattoo S, Cherry JD. Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies. Clin Microbiol Rev. 2005;18(2):326-382.
13. Decherd ME, Deskin RW, Rowen JL, et al. Bordetella pertussis causing otitis media: a case report. Laryngoscope. 2003;113(2):226-227.
14. Halperin SA, Marrie TJ. Pertussis encephalopathy in an adult: case report and review. Rev Infect Dis. 1991;13(6):1043-1047.
15. Trøseid M, Jonassen TØ, Steinbakk M. Isolation of Bordetella pertussis in blood culture from a patient with multiple myeloma. J Infect. 2006;52(1):e11-e13.
16. Cohen-Ganelin E, Davidovits M, Amir J, et al. Severe Bordetella pertussis infection associated with hemolytic uremic syndrome. Isr Med Assoc J. 2012l;14(7):456-458.
17. Chaturvedi S, Licht C, Langlois V. Hemolytic uremic syndrome caused by Bordetella pertussis infection. Pediatr Nephrol. 2010;25(7):1361-1364.
18. Pela I, Seracini D, Caprioli A, et al. Hemolytic uremic syndrome in an infant following Bordetella pertussis infection. Eur J Clin Microbiol Infect Dis. 2006;25(8):515-517.
19. Morrison W. Infantile hypertrophic pyloric stenosis in infants treated with azithromycin. Pediatr Infect Dis J. 2007;26(2):186-188.
20. Flore D. Diagnosis and treatment of multiple sclerosis and amyotrophic lateral sclerosis: neuropathies from Bordetella pertussis. Am J Ther. 2003;10(5):377-379.
21. Setta F, Baecke M, Jacquy J, et al. Cerebellar ataxia following whooping cough. Clin Neurol Neurosurg. 1999;101(1):56-61.
22. Janda W M, Santos E, Stevens J, et al. Unexpected isolation of Bordetella pertussis from a blood culture. J Clin Microbiol. 1994;32(11):2851-2853.
23. Melo N, Dias AC, Isidoro L, et al. Bordetella pertussis, an agent not to forget: a case report. Cases J. 2009;2(1):128.
24. vanderZeeA,AgterbergC,PeetersM,etal.Aclinicalvalidationof Bordetella pertussis and Bordetella parapertussis polymerase chain reaction: comparison with culture and serology using samples from patients with suspected whooping cough from a highly immunized population. J Infect Dis. 1996;174(1):89-96.
25. Birkebaek NH, Heron I, Skjødt K. Bordetella pertussis diagnosed by polymerase chain reaction. APMIS. 1994;102(4):291-294.
26. Gilberg S, Njamkepo E, Du Chatelet IP, et al. Evidence of Bordetella pertussis infection in adults presenting with persistent cough in a French area with very high whole-cell vaccine coverage. J Infect Dis. 2002;186(3):415-418.
27. Florax A, Ehlert K, Becker K, et al. Bordetella pertussis respiratory infection following hematopoietic stem cell transplantation: time for universal vaccination? Bone Marrow Transplant. 2006;38(9):639-640.
28. Senturk E, Sen S, Telli M. Empyema due to Bordetella pertussis in an adult patient with lung cancer [in English, Spanish]. Arch Bronconeumol. 2012;48(7):263-264.
29. MacLean DW. Bordetella pertussis infection in patients with bronchogenic carcinoma. Lancet. 1981;1(8218):503-504.
30. Suzuki N, Mizue N, Hori T, et al. Pertussis in adolescence after unrelated cord blood transplantation. Bone Marrow Transplant. 2003;32(9):967.
31. Dierig A, Beckmann C, Heininger U. Antibiotic treatment of pertussis: are 7 days really sufficient? Pediatr Infect Dis J. 2015;34(4):444-445.
32. Altunaiji S, Kukuruzovic R, Curtis N, et al. Antibiotics for whooping cough (pertussis). Cochrane Database Syst Rev. 2007;(3):CD004404.
33. Cooper WO, Griffin MR, Arbogast P, et al. Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis. Arch Pediatr Adolesc Med. 2002;156(7):647-650.
34. Santos N, Oliveira M, Galrinho A, et al. QT interval prolongation and extreme bradycardia after a single dose of azithromycin [in English, Portuguese]. Rev Port Cardiol. 2010;29(1):139-142.
35. Flanagan MP. How to manage a pertussis outbreak in your practice. Fam Pract Manag. 2005;12(7):31-34.
36. Guillot S, Descours G, Gillet Y, et al. Macrolide-resistant Bordetella pertussis infection in newborn girl, France. Emerg Infect Dis. 2012;18(6):966-968.
37. Lewis K, Saubolle MA, Tenover FC, et al. Pertussis caused by an erythromycin-resistant strain of Bordetella pertussis. Pediatr Infect Dis J. 1995;14(5):388-391.
38. Rubin LG, Levin MJ, Ljungman P, et al; Infectious Diseases Society of America. 2013 IDSA clinical practice guideline for vaccination of the immunocompromised host [Erratum appears in Clin Infect Dis. 2014;59(1):144]. Clin Infect Dis. 2014;58(3):e44-e100.
39. McGuiness CB, Hill J, Fonseca E, et al. The disease burden of pertussis in adults 50 years old and older in the United States: a retrospective study. BMC Infect Dis. 2013;13:32.
Source: Cancer Control.
Originally published April, 2016.