Side-Effect Management

Ibrutinib Therapy Linked to New, Worsened Hypertension

Ibrutinib-related hypertension associated with increased risk for major adverse cardiovascular events.

Preoperative Cachexia Predicts Poor Outcomes in Young Rather Than Elderly Gastric Cancer Patients: A Prospective Study

Background: Cachexia affects nearly 50–80% of cancer patients, and most studies have only focused on elderly patients. We investigated preoperative cachexia in gastric cancer (GC) patients by age group and comprehensively analyzed the impact of preoperative cachexia on the prognosis of GC patients in all age groups.Methods: In total, 575 patients were prospectively analyzed. The effect of…

Analysis of Thrombotic Events in Patients Receiving Ibrutinib

By

Sharon Ben Barouch, MD

Researchers found a low incidence of thrombotic events in patients receiving ibrutinib, though some patients still experienced bleeding.

ASCO Releases Guideline on Addressing Osteoporosis Risk With Nonmetastatic Cancer

By

Vicki Moore, PhD

The guideline includes strategies to identify patients with nonmetastatic cancer who may be at a higher risk for osteoporotic fractures

A Prospective Study on Urine Alkalization With an Oral Regimen Consisting of Sodium Bicarbonate and Acetazolamide in Patients Receiving High-dose Methotrexate

[Cancer Management and Research] Researchers sought an alternative regimen for urine alkalization in patients receiving high-dose methotrexate. The typical regimen, IV sodium bicarbonate, has been on shortage. This study determined the safety of an oral regimen of sodium bicarbonate and acetazolamide to achieve a urine pH >7, which is necessary for safe administration of high-dose methotrexate.

Understanding Chemotherapy-Associated Cognitive Decline: A Review of “Chemobrain”

By

John Schieszer

A review of what researchers are finding about “chemobrain,” a common adverse effect experienced by patients receiving chemotherapy for cancer.

Stepwise Intervention Can Help Cancer Survivors With Insomnia

By

Megan Garlapow, PhD

Novel treatment of insomnia helped almost half of the study population achieve remission of their insomnia after Step 1, with almost 80% of the remaining patients achieving remission of their insomnia after Step 2.

Recognition, Diagnosis of Chemotherapy-Induced Pheripheral Neuropathy in Cancer Patients Can Prevent Falls

By

John Schieszer, MA

A literature review identified CIPN as a potential contributor to falls and injuries in patients with cancer; however, evidence-based methods for preventing falls in these patients are scarce.

Durvalumab Still Beneficial Despite Association With Radiation Pneumonitis

By

Tiffany Garbutt, PhD

A substudy of the PACIFIC trial sought to determine if low-grade pneumonitis associated with durvalumab should deter its use in patients with NSCLC.

Efficacy of IV Ferric Carboxymalotose Similar to Traditional Treatments for Prevention of Chemotherapy-Induced Anemia

By

Tiffany Garbutt, PhD

Using a subset from the GeparOcto trial, researchers sought to determine if IV FCM was superior to physicians’ choice in treating chemotherapy-induced anemia in patients with breast cancer.