Female meningioma survivors are more likely to want and to intend to have a baby than the general population, according to research published in the Journal of Neurosurgery (2014; doi:10.3171/ 2014.11.JNS14522).

The diagnosis of a brain tumor, even one that’s usually benign and slow growing such as a meningioma, can be scary. Meningiomas can cause temporary and permanent side effects and sometimes may recur even after surgical removal.

In addition, a small percentage of primary or recurrent meningiomas are malignant. A further consideration for female meningioma survivors in their childbearing years is that some reports indicate that pregnancy may be a risk factor for tumor progression or recurrence.

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Researchers from Moffitt Cancer Center in Tampa, Florida, developed a survey to identify the impact of a meningioma diagnosis on women’s views about reproductive choices. In a preliminary study, the researchers surveyed women who had received a diagnosis of meningioma to ascertain their personal attitudes toward childbearing and what influences, such as physician recommendations, may have played a role in these attitudes.

The majority (70%) of surveyed female meningioma survivors 25 to 44 years of age claimed a strong desire to bear a child, and 27% of these respondents intended to have a baby in the future.

Survey respondents were recruited from female meningioma survivors participating in the online support group Meningioma Mommas. The online survey (MMS) was completed by 120 respondents, and it included questions concerning their childbearing desires and intentions as well as whether the risk of tumor recurrence and/or physicians’ recommendations influenced their decisions on reproduction. Of the respondents, 61 were ages 25 to 44 years.

The researchers compared these women’s responses with those of an age-matched group of women without meningioma who had participated in the 2010 National Survey of Family Growth (NSFG) and was deemed representative of the general population.

The researchers found that meningioma survivors who responded to the MMS were more likely to want a baby (70% vs 54%) and intend to have a baby (27% vs 12%) than women in the general population who responded to the NSFG. The meningioma survivors were also more confident about their intention to have a child (10% vs 2%).

The majority of respondents to the MMS (52%) reported that their physicians advised them about potential risk factors for meningioma recurrence. Nearly half of the respondents stated that pregnancy was one of those factors. The factor that most influenced childbirth intentions among the meningioma survivors was the risk of recurrent meningioma and the need for more treatment.

Although there have been case reports of concurrent meningioma and pregnancy, the researchers point out that there “are scant data on whether pregnancy induces the recurrence of meningioma.”

Nevertheless, “nearly half (43%) of the MMS respondents ages 25 to 44 [years] reported being told by a physician that pregnancy was a risk factor for recurrence, and approximately one-third (31%) reported that ‘medical advice against pregnancy’ influenced their birth desires and intentions.”

On the basis of the findings of this small, preliminary study, the researchers suggest that a larger patient-centered outcomes research study should be conducted to find whether pregnancy increases the risks of meningioma symptoms and recurrence. The results of that larger study would be beneficial in educating patients and physicians and would aid decision-making about childbearing in this patient population.