The anxiety experienced with a false-positive mammogramphy result is temporary and does not negatively impact a woman’s overall well-being, according to researchers.

Forty percent to 60% of women who undergo routine screening mammography during a 10-year period will experience a false-positive mammography result. Such results require additional testing, including possibly a biopsy, to confirm that cancer is not present.

Researchers have suspected that increased anxiety, pain, and the bother of additional tests might adversely affect the quality of life for women who experience false-positive mammography results. In this study, researchers from the Dartmouth-Hitchcock Norris Cotton Cancer Center in New Hampshire used data collected by the Digital Mammographic Imaging Screening Trial (DMIST) to study the impact a false-positive mammography result has on women’s lives. The study was published in JAMA Internal Medicine (2014; doi:10.1001/jamainternmed.2014.981).


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“Most policy analyses of breast cancer screening have used assumptions about the harms of screening on health and overall well-being based on expert opinion rather than patient-reported outcomes,” said principal author Anna N. A. Tosteson, ScD, of Dartmouth. “The DMIST study did not support these assumptions, and gave us evidence that a false-positive mammography experience has a limited impact on women’s overall well-being.”

The researchers studied personal anxiety and a standard measure of overall health and well-being often used by health economists to evaluate the effectiveness of health interventions. Attitudes toward future screening were measured by women’s intention to use breast screening in the future, and how much they would prefer to have a hypothetical new type of mammography with a lower chance of a false-positive result.

While false-positive mammograms were associated with a temporary increase in women’s anxiety, they had no measurable influence on overall health and well-being. Additionally, a false positive actually increased women’s intention to use breast cancer screening in the future, and did not increase how much women preferred the new mammography with fewer false positives. Another analysis showed that women’s anticipated anxiety about future false-positive mammograms was associated with a strong preference for the new type of mammography.

Tosteson noted that the study’s findings suggest that there is an opportunity to educate women about the false-positive mammography experience.

“With all the controversy about mammograms and whether they result in a net benefit or harm for women, it is important for women to be educated about possible screening outcomes. Women need to make informed decisions that are based on their own risks and preferences,” Tosteson said. “Our report can help those counseling women about breast cancer screening, and will also be useful to those developing mammography screening guidelines.”

She stresses that further evaluation is needed, and that several groups sponsored by the National Cancer Institute are actively studying mammography screening, including the PROSPR (Population-based Research Optimizing Screening through Personalized Regimens) Network and the Breast Cancer Surveillance Consortium.