Elderly, Non-Hispanic Blacks Less Likely to Receive Guideline-Concordant Treatment for Lung Cancer
Disparities between NCCN guideline-concordant treatment and actual care were most likely to occur in two patient populations.
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Caspofungin May Be More Effective Than Fluconazole in Lowering Risk of Invasive Fungal Disease in Young Patients With AML
Although this study was closed early because findings from an unplanned analysis suggested futility, the final analysis did not support that conclusion.
Gene Fusions Found in Pancreatic, Biliary IOPNs
Patterns of genetic alterations could guide management.
Integrating Nurse Assessments of Pain, Constipation Improved Documentation and Treatment
A quality improvement project achieved significant improvements in documentation and treatment planning after nurse assessments were included in provider care notes templates.
Characteristics Identified for Checkpoint Inhibitor-Resistant Patients
Patients with NSCLC who did not respond to immune checkpoint blockade had unique molecular characteristics, revealing possible therapeutic targets.
Long-Term Cancer Survivors Identify Ongoing Challenges Related to Ostomy Self-Management
In this study, researchers identified 8 common themes related to challenges patients experience with ostomy self-management.
FDA Grants Accelerated Approval to Brukinsa for Mantle Cell Lymphoma
Approval was based on data from a phase 2 trial that evaluated the safety and efficacy Brukinsa in 86 patients with MCL.
Reduced Rates of Central Nervous System Relapse in Patients With High-Risk Pediatric ALL
Central nervous system relapse rates in pediatric acute lymphoblastic leukemia can be reduced with additional early doses of intrathecal chemotherapy.
Outcomes Improved for Patients With AML and MDS Receiving Treosulfan/Fludarabine vs Busulfan/Fludarabine Conditioning Prior to HSCT
Researchers sought to determine if nonmyeloablative HSCT conditioning was noninferior to myeloablative approaches in more vulnerable patients with AML.
Exercise Intolerance, Neurocognitive Dysfunction in Survivors of Childhood Acute Lymphoblastic Leukemia
Exercise tolerance was found to be associated with verbal fluency, dominant motor speed, and math academics, among other neurocognitive metrics.
Triple-Drug Induction Therapy Yields Sustained Responses in Multiple Myeloma
Patients receiving the 3-drug treatment experienced increasing rates of complete response and measurable residual disease from induction through consolidation.
Patterns of Gabapentinoid Use Over Time in Patients With Cancer
A cross-sectional survey examined Medical Expenditure Panel Survey data on prescriptions for gabapentinoid medications given for pain management in patients with cancer.
Dietary Patterns May Possibly Be Linked to Prostate Cancer Risk
Plant-based diets might lower risk, animal-based diets containing dairy might raise risk for prostate cancer
Treosulfan May Offer a New Standard for Prehematopoietic Stem Cell Transplantation Conditioning
Patients receiving treosulfan and fludarabine experienced improved event-free and overall survival compared with patients receiving busulfan and fludarabine.
Monoclonal Gammopathy Type Associated With Prognosis in Patients With Diffuse Large B-Cell Lymphoma
Non-IgM monoclonal gammopathy was found to have an effect on progression-free survival and overall survival for patients with diffuse large B-cell lymphoma.
Survival Outcomes Associated With Infusion Reactions With Rituximab in Diffuse Large B-Cell Lymphoma
A retrospective cohort analysis found that patients with DLBCL who experienced infusion reactions during treatment with rituximab had prolonged overall survival. In addition, progression-free survival was affected in subsets of patients with DLBCL.
Biosimilar Truxima Now Available for Non-Hodgkin Lymphoma, Chronic Lymphocytic Leukemia
Truxima (rituximab-abbs; Teva and Celltrion), a biosimilar to Rituxan (rituximab; Genentech) will be available in the US the week of November 11, 2019 for the treatment of adults with non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL).
Single-Cell RNA Sequencing Characterizes T-Cell Impairment in CAR-T Cells Derived From Patients With CLL
This study investigated whether T-cell gene-expression profiles and other molecular characteristics of T-cell populations were associated with CAR-T performance.
RBC Count, Erythrocyte Sedimentation Rate May Be Useful Biomarkers of Polycythemia Vera
Although some red blood cell-related parameters used in the diagnosis of PV may be misleading in the setting of iron-deficiency, RBC count may be an effective biomarker for PV when combined with ESR.
Hematologic Scoring System Predicts Survival in Multiple Myeloma
A hematologic score based on specific blood parameters was evaluated for its potential to predict survival in patients with newly diagnosed multiple myeloma.
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