The addition of steroids to tuberculosis (TB) therapy can offer anti-inflammatory benefit to patients with tuberculous pericarditis, a rare cardiac manifestation of TB. But when these patients are co-infected with HIV this drug combination could increase the risk of cancer, according to the IMPI trial presented as a Hot Line at ESC Congress 2014 today and published simultaneously in the New England Journal of Medicine.

Findings from the study suggest “it may be reasonable to add steroids to regular treatment in TB pericarditis patients who don’t have HIV infection, but this strategy should be avoided in HIV infected individuals because of the increased risk of malignancy,” said investigator Bongani Mayosi, DPhil from Groote Schuur Hospital and the University of Cape Town, South Africa.

READ FULL ARTICLE Curated publisher From Medical Express