Kaiser Permanente Northern California, Division of Research 2Department of Family Medicine and Community Health, University of Pennsylvania Perelman School of Medicine 3Division of Research, Kaiser Permanente Northern California 4Division of Research, Kaiser Permanente 5Family Medicine and Community Health, University Of Pennsylvania Perelman School of Medicine ↵*Corresponding Author: Chyke A Doubeni, Family Medicine and Community Health, University Of Pennsylvania Perelman School of Medicine, 3400 Spruce Street, Gates 2, Philadelphia, PA, 19104, United States chyke.doubeni{at}uphs.upenn.edu Background: Existing literature suggests that metformin, the most commonly used biguanide, may lower colorectal cancer (CRC) risk.

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