(HealthDay News) — Phosphodiesterase type 5 inhibitor use after radical prostatectomy is associated with increased risk of biochemical recurrence, according to a study published in the February issue of The Journal of Urology.

Uwe Michl, from University Hospital Hamburg-Eppendorf in Germany, and colleagues examined the effect of phosphodiesterase type 5 inhibitors on biochemical recurrence after radical prostatectomy for prostate cancer. Data were included for 4,752 consecutive patients with localized prostate cancer treated with bilateral nerve-sparing radical prostatectomy. Of these, 23.4 percent received phosphodiesterase type 5 inhibitors postoperatively. The risk of biochemical recurrence was compared for those who did and did not receive phosphodiesterase type 5 inhibitors. Patients were followed for a median of 60.3 months.

The researchers found that the five-year biochemical recurrence-free survival estimates were 84.7 percent in the phosphodiesterase type 5 inhibitor group and 89.2 percent in the nonphosphodiesterase type 5 inhibitor group. Phosphodiesterase type 5 inhibitor use was an independent risk factor for biochemical recurrence (hazard ratio, 1.38) in multivariate regression analysis, and the correlation persisted after propensity score matching.

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“Contrary to experimental data, the use of phosphodiesterase type 5 inhibitors after radical prostatectomy may adversely impact biochemical recurrence,” the authors write.

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