Adding tumor-treating fields to maintenance temozolomide chemotherapy significantly prolonged progression-free survival and overall survival in patients with glioblastoma who had completed standard chemoradiation therapy, according to an interim analysis published in JAMA.1

Tumor-treating fields are a locoregionally delivered antimitotic treatment that disrupts cell division and organelle assembly.

Researchers sought to evaluate the efficacy and safety of tumor-treating fields in combination with temozolomide as maintenance therapy after chemoradiotherapy for patients with glioblastoma, the deadliest type of primary malignancy of the central nervous system in adults.


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For the study, researchers enrolled 315 patients with glioblastoma who had completed chemoradiotherapy. Participants were randomly assigned 2:1 to receive maintenance treatment with either tumor-treating fields delivered for more than 18 hours/day via 4 transducer arrays placed on the scalp and connected to a portable medical device plus temozolomide 150 to 200 mg/m2/day for 5 days of each 28-day cycle or temozolomide alone.

Results of an interim analysis showed that at a median follow-up of 38 months, median progression-free survival was 7.1 months (95% CI 5.9-8.2) in the combination arm and 4.0 months (95% CI 3.3-5.2) in the temozolomide alone arm (HR, 0.62; 98.7% CI 0.43-0.89; P=.001).

Researchers found that median overall survival was 20.5 months (95% CI 16.7-19.1) and 15.6 months (95% CI 13.3-19.1), respectively, (HR, 0.64; 99.4% CI 0.42-0.98; P=.004).

REFERENCE

1. Stupp R, Taillbert S, Kanner AA, et al. Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma. JAMA. 2015;314(23):2535-2543.