The following article features coverage from the 2021 Genitourinary Cancers Symposium meeting. Click here to read more of Oncology Nurse Advisor‘s conference coverage.

Female patients with bladder cancer who undergo radical cystectomy were found to show longer hospital stays and less home discharge than male patients did, according to a recent study, but the sexes did not differ in terms of major complications and other key outcomes at 30 days. The study’s results were presented at the American Society of Clinical Oncology 2021 Genitourinary Cancers Symposium.

Data from the American College of Surgeons National Surgical Quality Improvement Program were evaluated in this study for several outcomes in patients with bladder cancer, and the researchers compared several demographic and perioperative features by sex.

The researchers identified 4681 radical cystectomies in their search, with just under one-fifth (18.0%) being performed on females. Reportedly, there were not significant differences by sex in terms of age, frailty, American Society of Anesthesiologist risk score, or the use of a minimally invasive approach.

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However, female patients experienced a longer median length of hospital stay than did male patients (8 vs 7 days), had a longer median operative time (350 vs 336 min), and had a lower rate of discharge to home (79.9% vs 86.95%).

At 30 days, rates of reoperation were 4.76% and 5.96% for female and male patients, respectively (P =.173). Readmission also did not significantly differ by sex (22.24% vs 20.6%; P =.2904). Complications at a Clavien-Dindo classification of 3 to 5 also showed similar rates between sexes, at 16.64% and 16.51%, respectively. Deaths occurred in 1.9% of female patients and 2.01% of male patients (P =.8467).

The researchers concluded that radical cystectomies are performed far less often in female patients, who experience longer hospital stays and lower rates of home discharge than male patients, whereas rates of major complications, reoperation, and death at 30 days are similar between the sexes.

Read more of our coverage of the 2021 Genitourinary Cancers Symposium by visiting the conference page.


Kotamarti S, Silver M, Wood A, Teper E, Silver D, Schulman A. Do females have worse surgical outcomes after radical cystectomy? Impact of gender on 30-day complications in a national cohort. J Clin Oncol. 2021;39(suppl 6):abstr 402. doi:10.1200/JCO.2021.39.6_suppl.402