A study led by Princeton University researchers has revealed that the gene Metadherin— which is implicated in promoting the spread of breast cancer tumors— only stimulates tumor growth when the protein made by the gene interacts with a second protein known as SND1.
The researchers report in the journal Cancer Cellthat Metadherin, or MTDH, also plays a role in the initial growth of tumors, which occurs much earlier than the gene’s role in metastasis of the cancer to other parts of the body. In addition, the gene was not necessary for normal cell growth and development in mice, indicating that therapeutics that target this gene are likely to have a good safety profile, the researchers report.
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From Biosciencetechnology
