In conclusion, this is the first meta-analysis specifically assessing the role of AIs in advanced NSCLC according to histological types. The results of our study suggest that the addition of AIs to the treatment therapies for patients with lung adenocarcinoma offers an improved survival benefit when compared to non-AI-containing regimens. Prospective clinical trials investigating the role of AIs in this setting are recommended.

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Supported by Science and Technology Planning Project of Guangdong Province, People’s Republic of China (2009 B030801011) and Guangdong medical science research fund (B2012194, B2011100).


The authors report no conflicts of interest in this work.

Jian Zhang,1,* Jie Liu,2,* Huiguo Chen,1 Weibin Wu,1 Xiaojun Li,1 Yonghui Wu,1 Kai Zhang,1 Lijia Gu1
1Department of Thoracic Surgery, 2Department of Pharmacy, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, People’s Republic of China
*These authors contributed equally to this work. 


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Source: OncoTargets and Therapy.

Source: OncoTargets and Therapy.
Originally published September 1, 2015.