In summary, our comprehensive meta-analysis of all the published studies shows that addition of OFS does not appear to provide any additional benefits beyond those offered by adjuvant tamoxifen alone for premenopausal patients. Higher-risk patients who require chemotherapy might benefit from addition of OFS, but these results should be interpreted with caution because they were based on a smaller sample size and derived from only the SOFT and ZIPP trials. Further, exemestane plus OFS might be a better choice than tamoxifen plus OFS. Additional analyses and follow-up of the four studies might provide further insight into the use of OFS in combination with tamoxifen for the treatment of premenopausal women with early breast cancer.

Acknowledgment


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This research was supported by a grant from the National Science Foundation of China (81302313).


Shunchao Yan,1 Kai Li,1 Xin Jiao,2 Huawei Zou1

1Department of Oncology, Shengjing Hospital of China Medical University, 2Department of Respiratory Medicine, Shenyang Chest Hospital, Shenyang, People’s Republic of China.


Disclosure

The authors report no conflicts of interest in this work.


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Source: OncoTargets and Therapy.
Originally published on June 12, 2015.