There is a possibility of ultra-late recurrence developing over 10 years after the resection of any invasive NSCLC. Furthermore, lymphatic invasion is close to significantly influencing ultra-late recurrence.

A long follow-up period may be required in cases with adenocarcinoma with ALK-rearrangement because there is a possibility of its recurrence over 15 years after resection.

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Abbreviation list

NSCLC, non-small cell lung cancer; ALK, anaplastic lymphoma kinase; CT, computed tomography; EGFR, epidermal growth factor receptor; UICC, Union for International Cancer Control.


This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.


The authors report no conflicts of interest in this work.

Dai Sonoda,1,2 Yosuke Matsuura,1 Junji Ichinose,1 Masayuki Nakao,1 Hironori Ninomiya,3 Mingyon Mun,1 Yuichi Ishikawa,3 Ken Nakagawa,1 Yukitoshi Satoh,2 Sakae Okumura1

1Department of Thoracic Surgical Oncology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan; 2Department of Thoracic Surgery, Kitasato University School of Medicine, Sagamihara, Kanagawa 252-0374, Japan; 3Department of Pathology, The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan


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Source: Cancer Management and Research.
Originally published July 19, 2019.

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