CONCLUSIONS

Our analysis shows that in patients with NSCLC classified as N2 nodal disease, OS and PFS could be improved by adding PORT to chemotherapy and administering chemotherapy for more than four cycles. Our analysis shows that in patients with stage IIIA (N2) NSCLC, the OS and PFS can be improved by combining chemotherapy with adjuvant radiotherapy and administering chemotherapy for more than 4 cycles. PORT can improve the survival rate and local relapse-free survival rate in patients with N2-positive multistation lymph nodes. The EGFR mutation status was not associated with long-term survival. Therefore, the efficacy of chemotherapy combined with radiotherapy indicates that this treatment method should be widely used in the clinic. However, due to our small sample size, further evaluations of patients with N2 non-small-cell lung cancer undergoing surgical resection with EGFR mutations are required for clinical research and exploration.

Abbreviation list


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NSCLC, non-small cell lung cancer; PORT, Postoperative radiotherapy; OS, overall survival; EGFR, epidermal growth factor receptor mutation; ROCT, Postoperative chemotherapy; TKI, tyrosine kinase inhibitor; PCR, polymerase chain reaction; CT, computed tomography; MRI, magnetic resonance imaging; WHO, World Health Organization; PS, performance status; CTV, clinical target volume; PTV, planning target volume; FDG-PET/CT, fluorodeoxyglucose positron emission tomography computed tomography.

Acknowledgment

The authors thank Dong Guo for the support, revision and helpful suggestions.

Disclosure

The authors report no conflicts of interest in this work.


Ying Zhu,1–3,* Lei Fu,2,* Wang Jing,2 Li Kong,2,4 Jinming Yu2,4

1Department of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, People’s Republic of China; 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Jinan, People’s Republic of China; 3Heze Medical College Affiliated Hospital, Heze, Shandong Province, People’s Republic of China; 4Shandong Academy of Medical Sciences, Jinan, Shandong Province, People’s Republic of China

*These authors contributed equally to this work.

Correspondence: Jinming Yu
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, 440 Jinan Road, Jinan 250117, Shandong Province, People’s Republic of China
Tel +86 05 318 798 4777
Fax +86 05 318 798 4079
Email [email protected]


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Source: Cancer Management and Research.
Originally published December 31, 2019.

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