Pembrolizumab is another humanized anti-PD1 antibody and blocks the interaction between PD1 and its ligands. Pembrolizumab has also been approved for treating advanced melanoma in USA.38

Expression of PD-L1 in tumors can be a good indicator for objective responses to nivolumab; however, further analysis is required to find other biomarkers in the serum to anticipate the outcomes of nivolumab in future.


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Disclosure

The authors report no conflicts of interest in this work.


Emi Mashima, Akiha Inoue, Yumiko Sakuragi, Takashi Yamaguchi, Natsuko Sasaki, Yoko Hara, Daisuke Omoto, Shun Ohmori, Sanehito Haruyama, Yu Sawada, Manabu Yoshioka, Daisuke Nishio, Motonobu Nakamura

Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan


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Source: OncoTargets and Therapy.
Originally published on August 6, 2015.