In conclusion, results indicated that MWA is just as safe and effective as RFA for the treatment of HCC or liver metastases. Compared with RFA, MWA is associated with statistically significantly lower rates of LTP across analyses. Subgroup analyses showed that higher frequency (ie, 2450 MHz MWA) and larger tumor size (ie, >2.5 cm) may be associated with improved outcomes for MWA versus RFA. Further studies are required to assess the cost and time savings associated with MWA versus RFA as well as the comparison of MWA with non ablative strategies (eg, resection).

Data availability

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The dataset supporting the conclusions of this article is included in the article (and its supplementary data).

Abbreviation list

DFS, disease free survival; EHM, extrahepatic metastasis; HCC, hepatocellular carcinoma; IDL, intrahepatic de novo lesions; IRB, institutional review board; LOS, length of stay; LTP, local tumor progression; LTR, local tumor recurrence; MWA, microwave ablation; NOS, Newcastle–Ottawa quality assessment scale; OS, overall survival; PICOS, population intervention comparator outcomes study design; PRESS, peer review of electronic search strategies; PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses; RCT, randomized control trial; RFA, radiofrequency ablation; RoB, Cochrane risk of bias; RR, relative risk; TACE, transarterial chemoembolization; TAE, transarterial embolization; WMD, weighted mean difference.


This paper was presented at the Society of Interventional Oncology 2019 conference as a poster presentation with interim findings. The poster’s abstract was published online: This work was sponsored by Ethicon, Inc., who provided funding to conduct the analysis and prepare the manuscript.

Author contributions

All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.


SG, JWC, MBG, and JFA are employees of Ethicon, Inc. (manufacturer of Neuwave microwave ablation instrumentation). RAQ, NCF, BS, and GWJW are employees of Cornerstone Research Group, who were sponsored to perform this study by Ethicon, Inc. MBG reports stocks and stock options from Johnson & Johnson during the conduct of the study. The authors report no other conflicts of interest in this work.

Mrudula B Glassberg,1 Sudip Ghosh,2 Jeffrey W Clymer,3 Rana A Qadeer,4 Nicole C Ferko,4 Behnam Sadeghirad,4 George WJ Wright,4 Joseph F Amaral2
1Health Economics and Market Access, Ethicon Inc, Somerville, NJ, USA; 2Health Economics and Market Access, Ethicon Inc, Cincinnati, OH, USA; 3Medical Affairs, Ethicon Inc, Cincinnati, OH, USA; 4Cornerstone Research Group, Burlington, ON, Canada


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Source: Oncotargets and Therapy.
Originally published August 13, 2019.

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