CONCLUSION

The anti-CD79b ADC pola has shown promising activity in relapsed/refractory DLBCL and FL, and is currently FDA-approved in combination with bendamustine and rituximab in patients with relapsed/refractory DLBCL after at least two prior therapies. Myelosuppression and peripheral neuropathy are the main toxicities of pola. Pola has also shown encouraging preliminary results when combined with R-CHP in patients with previously untreated DLBCL and the results of the phase 3 trial of pola plus R-CHP vs R-CHOP will define if it has a role in the frontline treatment of DLBCL. Pola’s role in FL is less clear at this point as the combinations studied so far have failed to show a benefit over approved therapies. Given the wide expression of its target (CD79b), unique mechanism of action, and good safety profile, pola is a suitable candidate for combination studies in B-cell NHL. The results of ongoing clinical trials to confirm pola’s efficacy and investigate other potential combinations are eagerly awaited.

Disclosure

The authors report no conflicts of interest in this work.


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Yazeed Sawalha, Kami Maddocks

Department of Internal Medicine, Division of Hematology, Arthur G. James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH, USA

Correspondence: Yazeed Sawalha
Department of Internal Medicine, Division of Hematology, The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital, A350B Starling-Loving Hall, 320 W. 10th Ave., Columbus, OH 43210, USA
Tel +1 614-293-0837
Fax +1 614-293-7526
Email [email protected]


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Source: OncoTargets and Therapy.
Originally published June 8, 2020.

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