Over the past decades, checkpoint blockade strategies are evolving dramatically in the treatment of melanoma and numerous solid malignancies. Checkpoint immunotherapy has emerged as a promising treatment for breast cancer, especially for TNBC. However, monotherapy of immunoagents has a modest benefit in patients with metastatic disease. There is a growing interest in testing clinical activity and tolerability for incorporating cytotoxic agents, radiation, targeted therapies, or dual checkpoint blockade (Table 1). Despite the accumulating evidence supporting combination therapies, finding the best combination for individual patients will require to address the problems of developing predictive biomarkers and crucial selection of breast cancer patients who would benefit most from immunotherapy combinations. In general, an exciting new area of checkpoint immunotherapy is developing. The results of ongoing trials will be generated in the next few years. We hope to see these efforts translated into clinical benefits.

Table 1


The authors have declared that no competing interest exists in this work.

Zhi Bing Liu,1 Luyan Zhang,2 Jia Bian,3 Jinbo Jian1
1Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of China; 2Department of Oncology, Binzhou People’s Hospital, Binzhou, Shandong Province 256600, People’s Republic of China; 3Department of Radiology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of China

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Correspondence: Jinbo Jian
Department of Oncology, Binzhou Medical University Hospital, Binzhou, Shandong Province 256600, People’s Republic of China
Email [email protected]


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Source: OncoTargets and Therapy.
Originally published March 31, 2020.

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