Despite the multimodal treatment, patients with IBC still have particularly poor prognosis and high risk of early recurrence. Their survival rate remains significantly worse compared to patients with nonIBC.

An improved biological understanding of IBC suggesting the possibility of more personalized effective targeted therapies with the improvement of the clinical outcomes in these patients. The contribution of tumor microenvironment with the abundance of cytokines and chemokines to the disease is fundamental. Thus, cytokine blockade and immunotherapy may play a crucial role in the treatment of IBC in the future.


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We would like to acknowledge Denisa Manasova for her excellent technical help. We are grateful to all patients for their participation in the study.


This research was funded by the Slovak Research and Development Agency (APVV), grant number APVV-16-0010.


The authors declare no conflict of interest.

Barbora Dobiasova, Michal Mego

2nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Bratislava, Slovak Republic

Correspondence: Michal Mego
2 nd Department of Oncology, Comenius University, Faculty of Medicine, National Cancer Institute, Klenova 1, Bratislava 833 10, Slovak Republic
Tel +421-2-59378366
Fax +421-2-54774943
Email [email protected]


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Source: Breast Cancer: Targets and Therapy.
Originally published October 14, 2020.

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