Overall, the present case suggests that some NSCLC patients who develop a spectrum of cutaneous toxicities might have a good tumor response using erlotinib monotherapy. Our findings provide a method for clinicians to predict erlotinib efficacy in NSCLC therapy without knowledge of the EGFR mutation status. At a time when treatment is increasingly targeting tumor types and patients, exploring the connection between cutaneous toxicities and tumor response may aid in the identification of new clinical markers for treatment efficacy. Currently, for most of the reported studies, the primary outcome parameter was either response to therapy or overall survival. Reporting of toxicities was a secondary aim; thus, data collection has largely been obtained secondarily.18Therefore, there is lack of data in the literature on the frequency of cutaneous toxicities (in general) in non-responders compared to responders to EGFR inhibitor therapy. Future large-scale studies are needed to validate these findings.


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The authors have no conflict of interest to disclose.

Feng Jin,1 Hui Zhu,2 Li Kong,2 Jinming Yu2

1Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, University of Jinan, Jinan, People’s Republic of China; 2Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, People’s Republic of China


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Source: OncoTargets and Therapy.
Originally published on April 23, 2015.