Infusing paclitaxel without an inline filter

PDF of Ask A Pharmacist 0612

What are the potential problems associated with infusing paclitaxel (Taxol, generics) without an inline filter? —Tracy Hill

Paclitaxel should be administered through an in-line 0.22-micron or smaller filter to prevent microbubbles, any microbacterial contaminants, and particulates from infusing into the patient. Infusion of these may result in phlebitis, emboli, or other serious adverse effects. ONA

Lisa Thompson is assistant professor, Department of Clinical Pharmacy, University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado.

From the June 01, 2012 Issue of Oncology Nurse Advisor