Amifostine has also been studied to reduce nephrotoxicity with cisplatin. A study administering amifostine to patients with ovarian cancer who were receiving high doses of cisplatin (100mg/m2) demonstrated a reduction in the incidence of nephrotoxicity (defined as a ≥40% reduction in creatinine clearance) from 33% to 10% with the addition of amifostine. Amifostine is recommended by the American Society of Clinical Oncology for prevention of cisplatin-induced nephrotoxicity in patients with ovarian or non-small cell lung cancer who are receiving doses of cisplatin of 100mg/m2 or higher, however there is not data to support use of amifostine for this purpose in other settings.2

References


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1. Hensley ML, et al. American Society of Clinical Oncology 2008 Clinical Practice Guideline Update: Use of Chemotherapy and Radiation Therapy Protectants. J Clin Oncol 2009; 27(1):127-145.

2. Cisplatin prescribing information. WG Critical Care, LLC. Paramus, NJ. http://www.accessdata.fda.gov/drugsatfda_docs/label/2015/018057s083lbl.pdf Revised February 2015. Accessed July 14, 2015.