Nontypical Formulation of Pazopanib Effective, and Safe With Diligent Monitoring
Two cases studies demonstrate whether crushed pazopanib is a feasible alternative for patients who cannot swallow the tablets whole.
Sarcoma
Tumor Location, Histology Influence Clinical Outcomes of Primary Cardiac Sarcoma
A retrospective review revealed the association between tumor location, disease histology, and prognosis for patients with primary cardiac sarcoma.
Risk of Kaposi Sarcoma Supported by Its Evolving Clinicopathologic Characteristics
Antiretroviral therapy has led to a dramatic reduction in incidence of AIDS-related Kaposi sarcoma; however, changes in the disease may lead to a resurgence in its risk for people with HIV infection.
Prognostic Factors for Survival Among Patients With Primary Bone Sarcomas of Small Bones
[Cancer Management and Research] The prognostic values of overall survival and cancer-specific survival for bone sarcomas of the hands or feet were assessed using Cox proportional hazards regression model with univariate and multivariate analyses.
Elderly Patients Are Underrepresented in Trials For Soft Tissue Sarcoma
With median age of participants in clinical trials for soft-tissue sarcoma younger than most patients who develop the disease, these researchers sought to determine the prevalence of including persons older than 65 in clinical trials and the efficacy of first-line chemotherapy for STS in older patients.
Developments in the Management of Advanced Soft-tissue Sarcoma – Olaratumab in Context
[OncoTargets and Therapy] This review examines the rationale of olaratumab in the treatment of advanced soft-tissue sarcomas and its emerging role in clinical practice.
Exercise May Mitigate Cardiotoxicity Associated With Doxorubicin Treatment
Researchers injected Ewing sarcoma cells into mice to determine the effects of exercise on doxorubicin efficacy and treatment-related cardiotoxicity.
Vitamin D Supplementation is Recommended for Use in Young Patients With Sarcoma
Just over half of patients in a standard therapy group had normal bone mineral density after a mean follow-up of 6 years; this contrasted with 93% of patients in a vitamin D supplementation group.
Progression-Free, Overall Survival in Liposarcoma Improved With Eribulin vs Dacarbazine
Comparison study shows significantly improved overall survival and progression-free survival in patients with advanced LPS treated with eribulin vs dacarbazine.
Regional Chemotherapy Technique May Help Prevent Amputations
Researchers indicate that it may be possible lower amputation rates by nearly 80% in patients with extremity sarcomas.
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