Dr Preisser and his colleagues analyzed the subgroup of patients who underwent RARP and found that the effect of patient age on the risk of overall and other complications was similar to that of the entire cohort.

Most men who undergo RP are aged 45 to 75 years, the authors noted, but with an aging population, physicians will need to separate biological age from chronological age and provide individualized care.

In addition to its retrospective design, limitations of the study included an inability to adjust for tumor characteristics. “Indeed, patients with locally advanced PCa may suffer from a higher complication rate than those with localized cancers,” the authors wrote. “It is possible that a larger proportion of elderly patients may have harbored more advanced PCa at the time of RP.”

Dr Preisser’s team also pointed out that they were unable to adjust for other cancer-related variables, such as the use of neoadjuvant chemotherapy, neoadjuvant androgen deprivation therapy, and preoperative radiotherapy, in addition to some patient characteristics, such as performance status, differences in laboratory values, and opioid use.

Gerald Andriole, MD, Professor and Chief of the Division of Urologic Surgery at Washington University School of Medicine in St. Louis, Missouri, said the new study validates the importance of considering age when recommending RP and provides important data for clinicians when counseling their patients.

“Even with adjustment for common baseline co-morbidities, rising age was associated with higher rates of certain post-op complications,” Dr Andriole told Renal & Urology News. “This observation validates the guidelines of many entities, such as the NCCN [National Comprehensive Cancer Center] and the AUA [American Urological Association], that before recommending radical prostatectomy to men with aggressive prostate cancer, surgeons should be confident that the patient has a high probability of at least a 10- to 15-year survival.”

James Mohler, MD, Professor of Oncology and Chief of Inter-Institutional Academics at Roswell Park Comprehensive Cancer Center, Buffalo, New York, said he is not surprised by the study findings. NCCN has advocated for considering physiological age/life expectancy versus chance of PCa-related death and chance of cure versus chance of complications when counseling patients regarding the various treatment options for localized PCa (observation, active surveillance, surgery, and radiation).

Dr Mohler, who chairs the NCCN Clinical Practice Guidelines in Oncology Panel for Prostate Cancer, said the guidance provided by this current study may help improve outcomes. “First, the findings may stimulate more complete discussions of radical prostatectomy as a treatment option. Second, the findings should help raise awareness that chronologic and physiologic age are different.”

Reference

Preisser F, Mazzone E, Nazzani S, et al. Impact of age on perioperative outcomes at radical prostatectomy: A population-based study. Eur Urol Focus 2018; published online ahead of print.

This article originally appeared on Renal and Urology News