(HealthDay News) — Multilevel, provider-oriented interventions may improve human papillomavirus (HPV) vaccine series initiation and completion, according to a study published in the June 1 issue of Pediatrics.

Rebecca B. Perkins, M.D., from the Boston University School of Medicine and Boston Medical Center, and colleagues evaluated the effectiveness of a seven-session program (interprofessional provider education, communication training, data feedback, and tailored systems change). The program was delivered at five pediatric and/or family medicine practices between 2016 and 2018. Vaccination rates among 9- to 17-year-olds were compared for the preintervention, intervention, and postintervention periods.

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The researchers found that in the intervention and postintervention periods, the adjusted likelihood of vaccination at an eligible visit increased by >10 percentage points for ages 9 to 10 and 11 to 12 years, while completion of the vaccine series by age 13 years increased by 4 percentage points. Population-level vaccine initiation coverage increased from 75 percent preintervention to 90 percent postintervention. Completion increased from 60 percent preintervention to 69 percent postintervention.

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“Because multilevel interventions require substantial investments of personnel and time in the short-term, demonstrating that intervention effects continue in the postintervention period is important when clinical and policy decision-makers consider upfront costs,” the authors write.

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