Currently, there are ongoing phases II and phase III clinical trials attempting to clarify the role of HIPEC for the treatment of EOC. Literature suggests that in appropriately selected patient populations, HIPEC may confer both a PFS and OS benefit. Our data supports a reasonable side effect profile of several HIPEC regimens for patients with EOC for multiple treatment indications. Future studies designed to determine which cytotoxic agents would provide the most benefit in patients with EOC are needed.
Michelle M. Boisen1, Scott D. Richard2, Matthew P. Holtzman3, Robert P. Edwards1, Joseph L. Kelley1, Mohammad Haroon Choudry3, David Bartlett3, Marilyn Huang1
1Division of Gynecologic Oncology, Magee-Womens Hospital of UPMC, Pittsburgh, PA, USA; 2Division of Gynecologic Oncology, Hahnemann University Hospital, Philadelphia, PA, USA; 3Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
Contributions: (I) Conception and design: MM Boisen, M Huang; (II) Administrative support: M Huang, MH Choudry; (III) Provision of study materials or patients: SD Richard, MP Holtzman, MH Choudry, D Bartlett, RP Edwards, M Huang; (IV) Collection and assembly of data: MM Boisen, M Huang, SD Richard, MP Holtzman, MH Chourdry; (V) Data analysis and interpretation: MM Boisen, M Huang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.
Correspondence to: Michelle M. Boisen, MD. Magee-Womens Hospital of UPMC, 300 Halket St., Suite 2130, Pittsburgh, PA 15213, USA. Email: [email protected].
Conflicts of Interest: The authors have no conflicts of interest to declare.
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