Ovarian Cancer

Efficacy and Safety of Olaparib Maintenance Therapy in Platinum-sensitive Ovarian Cancer Patients With BRCA Mutations: A Meta-Analysis on Randomized Controlled Trials

By

Rick Maffei

Publish Date June 7, 2019

[Cancer Management and Research] A meta-analysis of randomized controlled trials sought to confirm the effectiveness and safety of olaparib for the treatment of relapsed BRCA-mutated ovarian cancer.

Intraperitoneal Chemotherapy Fails to Improve Outcomes in Advanced Ovarian Carcinoma

By

Christina Bennett, MS

Publish Date May 24, 2019

When paired with bevacizumab, neither intraperitoneal delivery of carboplatin nor cisplatin improved outcomes for patients with advanced ovarian carcinoma compared with intravenous delivery.

Mirvetuximab Soravtansine Data Lacking for FDA’s Accelerated Approval in Ovarian CA

By

Brian Park, PharmD

Publish Date May 16, 2019

The Food and Drug Administration (FDA) has recommended that ImmunoGen, Inc. conduct a new phase 3 randomized trial to evaluate the safety and efficacy of mirvetuximab soravtansine (IMGN853) in patients with high folate receptor alpha (FRα)-positive, platinum-resistant ovarian cancer.

Late-Line Niraparib in Advanced Ovarian Cancer: A Continuum of Clinical Benefit in Subgroups Characterized by Clinical and Molecular Biomarkers

By

Susan Moench, PhD, PA-C

Publish Date May 8, 2019

More accurate biomarkers are needed to better define subgroups of patients with ovarian cancer who are most likely to benefit from late-line niraparib.

ePRO Tool Improves Symptom Management in an Outpatient Gynecologic Cancer Clinic

By

Susan Moench, PhD, PA-C

Publish Date April 1, 2019

Investigators sought to determine if electronic patient-reported outcome tools with the PROMIS network improved identifying patients with severe symptoms and increased referrals to ancillary support services.

Ovarian Cancer Clinical Trials

Clinical Trial: Specimen and Data Study for Ovarian Cancer Early Detection and Prevention

Clinical Trial: Prophylactic Salpingectomy With Delayed Oophorectomy

Clinical Trial: Interactive Educational Website for Women With Ovarian Cancer & Caregivers

Clinical Trial: Veliparib and Topotecan for Relapsed Ovarian Cancer With Negative or Unknown BRCA Status

Clinical Trial: AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer