Central nervous system involvement is also rare and occurs in only 1% of all multiple myeloma cases. However, patients with an alteration in chromosome 13 and translocation (4;14), both of which were detected in this patient, have been found to have a higher risk.
“Even with the knowledge of her high-risk cytogenetics, this case of myeloma relapse was profoundly rapid and aggressive,” report the authors. “Following HSCT, she demonstrated a small disease burden on routine laboratory surveillance. The fact that she relapsed with simultaneous intracranial plasmacytoma and malignant pericardial effusion is unusual, likely reflecting an aggressive myeloma which had already failed treatment with multiple chemotherapy agents.”
1. Pan J, Chen J, and Filicko J, et al. Relapsed multiple myeloma presenting as intracranial plasmacytoma and malignant pericardial effusion following recent allogeneic stem cell transplantation. Case Rep Oncol. 2017;10(2):582-587.