Older age and presence of a T-cell clone in lymphomatoid papulosis (LyP) lesions are risk factors for associated lymphomas in patients with LyP, according to the results of a study published online ahead of print in The Oncologist.1

LyP is an indolent cutaneous lymphoma and its prognosis is excellent; however, prognosis is worse if LyP is associated with lymphoma. Risk factors and frequency of this association are unclear, prompting researchers to assess these concerns in an 11-year retrospective study conducted in 8 dermatology departments with the French Study Group on Cutaneous Lymphoma (FSGCL).

This study used data extracted from the FSGCL registry from 1991 to 2006 on patients with LyP who were followed up to January 2014. The researchers recorded age, sex, number of skin lesions, histologic subtype, and genotype at baseline; univariate and multivariate analysis were used to determine risk factors; and Kaplan-Meier method was used to calculate cumulative probability of association.

The researchers identified 52 cases of lymphomas in 44 of 106 patients. Lymphoma was diagnosed with or before LyP diagnosis in 31 cases and was diagnosed during the course of LyP in 21 cases. Multivariate analysis revealed the main prognostic factors for association between LyP and another lymphoma were older age (odds ratio [OR] 1.05 per year; 95% confidence interval [CI] 1.01–1.08; p = .011) and presence of a T-cell clone in LyP lesions (OR 7.55; 95% CI 2.18–26.18; P=.001).


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“The results presented here demonstrate a high rate of association between LyP and other lymphomas (41%) as well as a long median delay of occurrence (5 years), which emphasizes the need for prolonged follow-up of patients with LyP,” the researchers reported. Furthermore, the study highlighted two main risk factors, older age and presence of a T-cell clone in LyP lesions, that can help clinicians identify those patients who need to be closely managed.

REFERENCE

1. Cordel N, Tressières B, D’Incan M, et al. Frequency and risk factors for associated lymphomas in patients with lymphomatoid papulosis [published online ahead of print December 14, 2015]. Oncologist. doi:10.1634/theoncologist.2015-0242.