In summary, our results suggest NSCLC patients with BMs benefited from the combination and sequential therapies of EGFR-TKIs, chemotherapy and RT (WBRT or SRS). In addition, patients with the EGFR exon 19 deletion may have a better OS than patients with the exon 21 L858R mutation. However, the optimal timing of RT interval remains to be explored. And the ideal sequence about the application of third- or even fourth-generation EGFR-TKIs is unclear. Furthermore, immunotherapy provides a new treatment option. Larger prospective randomized clinical trials are urgently needed to explore the optimal treatment combination for BM in patients with EGFR-mutant NSCLC.


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The authors report no conflicts of interest in this work.

Haiyang Wang,1,* Xiaoqing Yu,1,* Yun Fan,2 Youhua Jiang2

1Department of Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, People’s Republic of China; 2Key Laboratory of Diagnosis and Treatment Technology on Thoracic Oncology (Esophagus, Lung), Zhejiang Cancer Hospital, Hangzhou, Zhejiang, People’s Republic of China

*These authors contributed equally to this work 


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Source: OncoTargets and Therapy.
Originally published April 13, 2018.