Manchester scientists are working out how to safely increase the radiotherapy dose given to lung cancer patients – potentially offering improved local control and survival.

Standard treatment for locally advanced non-small cell lung cancer is a combination of radiotherapy and chemotherapy. Traditionally this is planned in a one-size-fits-all manner but the radiation dose may not always be enough to stop tumour growth. The potential to increase the radiation dose to the cancerous tissue varies between patients and depends on the size and location of the tumour in relation to sensitive organs such as the spinal cord and lungs.

Now researchers at The University of Manchester and The Christie NHS Foundation Trust – both part of the Manchester Cancer Research Centre – have looked at ways to personalise and increase the dose to the tumour while minimising the effect on healthy tissue.

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