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The findings of this meta-analysis indicate that the XRCC1 Arg399Gln SNP is associated with increased risk of childhood ALL in Asians. Large-scale studies should be conducted in the future to verify these results.


This work was supported by the Natural Science Foundation of Shaanxi Province (number 2015JM8415) and the Fundamental Research Funds for the Central Universities of China (number 08143047).


The authors report no conflicts of interest in this work.

Fang Wang,1,2,* Qian Zhao,1,2,* Hai-rong He,3 Ya-jing Zhai,4 Jun Lu,3 Hai-bo Hu,1 Jin-song Zhou,Yong-hua Yang,5 Yuan-jie Li1

1Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Centre, 2College of Pharmacy, Xi’an Medical University, 3Clinical Research Center, 4Department of Pharmacy, 5Department of Pediatrics, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, People’s Republic of China

*These authors contributed equally to this work  


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Source: OncoTargets and Therapy
Originally published November 6, 2015.