The findings of this meta-analysis indicate that the XRCC1 Arg399Gln SNP is associated with increased risk of childhood ALL in Asians. Large-scale studies should be conducted in the future to verify these results.
This work was supported by the Natural Science Foundation of Shaanxi Province (number 2015JM8415) and the Fundamental Research Funds for the Central Universities of China (number 08143047).
The authors report no conflicts of interest in this work.
Fang Wang,1,2,* Qian Zhao,1,2,* Hai-rong He,3 Ya-jing Zhai,4 Jun Lu,3 Hai-bo Hu,1 Jin-song Zhou,1 Yong-hua Yang,5 Yuan-jie Li1
1Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Centre, 2College of Pharmacy, Xi’an Medical University, 3Clinical Research Center, 4Department of Pharmacy, 5Department of Pediatrics, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, People’s Republic of China
*These authors contributed equally to this work
1. Huang Y, Xie D, Tang N, et al. XRCC1 Arg399Gln variation and leukemia susceptibility: evidence from 2,647 cases and 5,518 controls. Tumour Biol. 2014;35(1):799–808.
2. Zhang H, Liu H, Jiang G. Genetic polymorphisms of XRCC1 and leukemia risk: a meta-analysis of 19 case-control studies. PLoS One. 2013; 8(11):e80687.
3. Seedhouse C, Bainton R, Lewis M, Harding A, Russell N, Das-Gupta E. The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. Blood. 2002;100(10):3761–3766.
4. Berwick M, Vineis P. Markers of DNA repair and susceptibility to cancer in humans: an epidemiologic review. J Natl Cancer Inst. 2000;92(11):874–897.
5. Ginsberg G, Angle K, Guyton K, Sonawane B. Polymorphism in the DNA repair enzyme XRCC1: utility of current database and implications for human health risk assessment. Mutat Res. 2011;727(1–2):1–15.
6. Higgins JP1, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–560.
7. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177–188.
8. Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test.BMJ. 1997;315(7109):629–634.
9. Banescu C, Duicu C, Trifa AP, Dobreanu M. XRCC1 Arg194Trp and Arg399Gln polymorphisms are significantly associated with shorter survival in acute myeloid leukemia. Leuk Lymphoma. 2014;55(2):365–370.
10. Sorour A, Ayad MW, Kassem H. The genotype distribution of the XRCC1, XRCC3, and XPD DNA repair genes and their role for the development of acute myeloblastic leukemia. Genet Test Mol Biomarkers. 2013;17(3):195–201.
11. Kim HN, Kim NY, Yu L, et al. Association of GSTT1 polymorphism with acute myeloid leukemia risk is dependent on smoking status. Leuk Lymphoma. 2012;53(4):681–687.
12. Ozcan A, Pehlivan M, Tomatir AG, et al. Polymorphisms of the DNA repair gene XPD (751) and XRCC1 (399) correlates with risk of hematological malignancies in Turkish population. Afr J Biotechnol. 2011; 10(44):8860–8870.
13. Goricar K, Erculj N, Faganel Kotnik B, et al. The association of folate pathway and DNA repair polymorphisms with susceptibility to childhood acute lymphoblastic leukemia. Gene. 2015;562(2):203–209.
14. Dincer Y, Yuksel S, Batar B, Guven M, Onaran I, Celkan T. DNA repair gene polymorphisms and their relation with DNA damage, DNA repair, and total antioxidant capacity in childhood acute lymphoblastic leukemia survivors. J Pediatr Hematol Oncol. 2015;37(5):344–350.
15. Stanczyk M, Sliwinski T, Cuchra M, et al. The association of polymorphisms in DNA base excision repair genes XRCC1, OGG1 and MUTYH with the risk of childhood acute lymphoblastic leukemia. Mol Biol Rep. 2011;38(1):445–451.
16. Canalle R, Silveira VS, Scrideli CA, Queiroz RG, Lopes LF, Tone LG. Impact of thymidylate synthase promoter and DNA repair gene polymorphisms on susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma. 2011;52(6):1118–1126.
17. Tumer TB, Yilmaz D, Tanrikut C, Sahin G, Ulusoy G, Arinc E. DNA repair XRCC1 Arg399Gln polymorphism alone, and in combination with CYP2E1 polymorphisms significantly contribute to the risk of development of childhood acute lymphoblastic leukemia. Leuk Res. 2010;34(10):1275–1281.
18. Meza-Espinoza JP, Peralta-Leal V, Gutierrez-Angulo M, et al. XRCC1 polymorphisms and haplotypes in Mexican patients with acute lymphoblastic leukemia. Genet Mol Res. 2009;8(4):1451–1458.
19. Batar B, Guven M, Baris S, Celkan T, Yildiz I. DNA repair gene XPD and XRCC1 polymorphisms and the risk of childhood acute lymphoblastic leukemia. Leuk Res. 2009;33(6):759–763.
20. Celkan T, Guven M, Batar B, Alhaj S. The difference between pre-B cell acute lymphoblastic leukemia and Burkitt lymphoma in relation to DNA damage repair gene polymorphisms in childhood. Leuk Lymphoma. 2008;49(8):1638–1640.
21. Pakakasama S, Sirirat T, Kanchanachumpol S, et al. Genetic polymorphisms and haplotypes of DNA repair genes in childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007;48(1):16–20.
22. Joseph T, Kusumakumary P, Chacko P, Abraham A, Pillai MR. DNA repair gene XRCC1 polymorphisms in childhood acute lymphoblastic leukemia. Cancer Lett. 2005;217(1):17–24.
23. Duman N, Aktan M, Ozturk S, et al. Investigation of Arg399Gln and Arg194Trp polymorphisms of the XRCC1 (x-ray cross-complementing group 1) gene and its correlation to sister chromatid exchange frequency in patients with chronic lymphocytic leukemia. Genet Test Mol Biomarkers. 2012;16(4):287–291.
24. Abramenko I, Bilous N, Chumak A, Kostin A, Martina Z, Dyagil I. DNA repair polymorphisms in B-cell chronic lymphocytic leukemia in sufferers of Chernobyl Nuclear Power Plant accident. J Radiat Res. 2012;53(3):497–503.
25. Ganster C, Neesen J, Zehetmayer S, et al. DNA repair polymorphisms associated with cytogenetic subgroups in B-cell chronic lymphocytic leukemia. Genes Chromosomes Cancer. 2009;48(9):760–767.
26. Banescu C, Trifa AP, Demian S, et al. Polymorphism of XRCC1, XRCC3, and XPD genes and risk of chronic myeloid leukemia. Biomed Res Int. 2014;2014:213790.
27. Annamaneni S, Gorre M, Kagita S, et al. Association of XRCC1 gene polymorphisms with chronic myeloid leukemia in the population of Andhra Pradesh, India. Hematology. 2013;18(3):163–168.
28. Deligezer U, Akisik EE, Dalay N. Lack of association of XRCC1 codon 399Gln polymorphism with chronic myelogenous leukemia. Anticancer Res. 2007;27(4B):2453–2456.
29. Swinney RM, Beuten J, Collier AB 3rd, et al. Polymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children. Cancer Epidemiol Biomarkers Prev. 2011;20(7): 1537–1542.
30. Bhatia S, Sather HN, Heerema NA, Trigg ME, Gaynon PS, Robison LL. Racial and ethnic differences in survival of children with acute lymphoblastic leukemia. Blood. 2002;100(6):1957–1964.
31. Zeng X, Zhang Y, Kwong JS, et al. The methodological quality assessment tools for preclinical and clinical studies, systematic review and meta-analysis, and clinical practice guideline: a systematic review. J Evid Based Med. 2015;8(1):2–10.
32. Zhang Y, Zhang J, Zeng L, et al. The -2518A/G polymorphism in the MCP-1 gene and tuberculosis risk: a meta-analysis. PLoS One. 2012;7(7):e38918.
33. MacArthur AC, McBride ML, Spinelli JJ, Tamaro S, Gallagher RP, Theriault G. Risk of childhood leukemia associated with parental smoking and alcohol consumption prior to conception and during pregnancy: the cross-Canada childhood leukemia study. Cancer Causes Control. 2008;19(3):283–295.
34. Ozdemir N, Celkan T, Baris S, Batar B, Guven M. DNA repair gene XPD and XRCC1 polymorphisms and the risk of febrile neutropenia and mucositis in children with leukemia and lymphoma. Leuk Res. 2012;36(5):565–569.
Source: OncoTargets and Therapy
Originally published November 6, 2015.