A key study finding was no significant differences in the rates of bacteremia for patients managed in an OP vs an IP setting following induction II (19.3% vs 21.5%), intensification I (26.0% vs 28.5%), and intensification II (32.1% vs 46.1%) courses, and in all courses overall (23.8% vs 29.0%). (No analysis was performed after induction I because only 8.7% of patient management was conducted in an OP setting.) In addition, the number of days to next course were similar in these 2 groups (30.3 in OP setting vs 31.6 in IP setting; P =.17).

Semistructured interviews conducted with patients/family members at 9 centers did not reveal differences in rates of satisfaction with management setting, with 85% and 86% of patients’ families expressing satisfaction with treatment in the IP and OP settings, respectively. In addition, parent proxy Peds QOL scores did not differ with management setting.

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Although the study authors concluded that OP management during neutropenia may be appropriate for some children with AML following intensive chemotherapy, they cautioned that “implementation studies are needed to identify patient/family characteristics that portend a positive experience with an OP strategy.”


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Disclosure: Multiple authors declared affiliations with industry. Please refer to the original abstract for a full list of disclosures.

Reference

Getz KD, Li Y, Szymczak JE, et al. Home or away from home: a multi-institution study comparing medical outcomes, patient perspectives, and health-related quality of life for outpatient versus inpatient management after chemotherapy for pediatric acute myeloid leukemia. Oral presentation at: 61st ASH Annual Meeting & Exposition; December 7-10, 2019; Orlando, FL. Abstract 379.