A key finding of this study was that 47% (n=45) of those patients admitted to the ICU survived to be discharged from the hospital, with 35% (n=34) and 30% (n=29) alive 90 days and 1 year following hospital discharge, respectively. Importantly, in the subgroup of patients alive at 90 days following ICU admission, the mean Eastern Cooperative Oncology Group-Performance Status (ECOG-PS) score was 1.28 following ICU discharge, and 68% were independent with respect to activities of daily living at post-ICU assessment.
In contrast, a multivariate analysis of factors associated with in-hospital mortality included a higher preadmission ECOG-PS score (odds ratio [OR], 2.76; 95% CI,
1.24-6.12; P =.013), and a requirement for more than 1 life-sustaining therapy — invasive ventilation, vasopressors, and/or acute renal replacement therapy — while in the ICU (OR, 12.39; 95% CI, 3.10-49.48; P <.001).
The study authors opined that “these findings support the judicious use of ICU resources for older patients with AML, particularly those with a good performance status, and can better inform patient-clinician discussions regarding ICU outcomes in this population.”
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