A key finding of this study was that 47% (n=45) of those patients admitted to the ICU survived to be discharged from the hospital, with 35% (n=34) and 30% (n=29) alive 90 days and 1 year following hospital discharge, respectively. Importantly, in the subgroup of patients alive at 90 days following ICU admission, the mean Eastern Cooperative Oncology Group-Performance Status (ECOG-PS) score was 1.28 following ICU discharge, and 68% were independent with respect to activities of daily living at post-ICU assessment.

In contrast, a multivariate analysis of factors associated with in-hospital mortality included a higher preadmission ECOG-PS score (odds ratio [OR], 2.76; 95% CI,

1.24-6.12; P =.013), and a requirement for more than 1 life-sustaining therapy — invasive ventilation, vasopressors, and/or acute renal replacement therapy — while in the ICU (OR, 12.39; 95% CI, 3.10-49.48; P <.001).


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The study authors opined that “these findings support the judicious use of ICU resources for older patients with AML, particularly those with a good performance status, and can better inform patient-clinician discussions regarding ICU outcomes in this population.”

References

1. Slavin SD, Fenech A, Jankowski AL, et al. Outcomes for older adults with acute myeloid leukemia after an intensive care unit admission [published online July 12, 2019]. Cancer. doi: 10.1002/cncr.32397 2. Jackson K, Mollee P, Morris K, et al. Outcomes and prognostic factors for patients with acute myeloid leukemia admitted to the intensive care unit. Leuk Lymphoma. 2014;55(1):97-104.