Chronic Myeloid Leukemia‎

Early Monitoring of Chronic Myeloid Leukemia Might Dictate TKI Switch

By

Leah Lawrence

Publish Date April 24, 2020

Lack of initial response to imatinib might indicate need to switch to dasatinib.

Radotinib May Have Similar Efficacy to Imatinib in Chronic Myeloid Leukemia

By

Jonathan Goodman, MPhil

Publish Date March 2, 2020

Researchers reported long-term follow-up results from the phase 3 RERISE study, which assessed the efficacy of radotinib compared with imatinib for CML treatment.

Asciminib Shows Clinical Activity for Pretreated CML in Phase 1 Trial

By

Christina Bennett, MS

Publish Date January 16, 2020

Asciminib appeared to have clinical activity in a population of heavily pretreated patients with chronic myeloid leukemia, including those with a T315I mutation.

Monitoring Disease Recurrence With Patient-Reported Outcomes After Discontinuation of Tyrosine Kinase Inhibitor Therapy

By

Tiffany Garbutt, PhD

Publish Date December 10, 2019

Results of LAST, the largest study on TKI discontinuation, support using patient-reported outcomes when monitoring remission and symptoms in patients who discontinue TKI therapy.

Follow-Up Results of Low-Dose Dasatinib for Chronic-Phase Chronic Myeloid Leukemia

By

Vicki Moore, PhD

Publish Date October 28, 2019

Patients received 50 mg dasatinib daily and demonstrated 2-year rates of overall and event-free survival of 100%.

Leukemia Clinical Trials

Clinical Trial: Molecular Epidemiology of Childhood Leukemia (Aka The California Childhood Leukemia Study) (CCLS)

Clinical trial focusing on the molecular epidemiology of childhood leukemia. Molecular Epidemiology of Childhood Leukemia (Aka The California Childhood Leukemia Study) (CCLS)

Clinical Trial: Genetic Study of Chronic Lymphocytic Leukemia Families

Clinical trial focusing on genetics and chronic lymphocytic leukemia. Genetic Study of Chronic Lymphocytic Leukemia Families

Clinical Trial: Banking of Chronic Lymphocytic Leukemia Tumor Cells for Vaccine Generation

Clinical trial focusing on vaccine generation from chronic lymphocytic leukemia tumor cells. Banking of Chronic Lymphocytic Leukemia Tumor Cells for Vaccine Generation

Clinical Trial: Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia

Clinical trial focusing on GNKG168. Phase I Study of GNKG168 in Acute Lymphoblastic Leukemia and Acute Myelogenous Leukemia

Clinical Trial: Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL)

Clinical trial focusing on carfilzomib Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL). Study of Carfilzomib in Chronic Lymphocytic Leukemia (CLL), Small Lymphocytic Lymphoma (SLL) or Prolymphocytic Leukemia (PLL) .