Results of a new study showed that higher preoperative blood glucose (POBG) was linked to prolonged length of stay (LOS) in patients with renal cell carcinoma (RCC) who underwent laparoscopic nephrectomy. These results were published in the journal Frontiers in Surgery.

“To our knowledge, this is the largest and first study of the relationship between POBG and hospital LOS in Chinese patients undergoing laparoscopic nephrectomy,” the researchers wrote in their report.

The retrospective study utilized a database from the Zhongda Hospital in Nanjing, China, including information from patients with urinary malignancies. This analysis involved adults with RCC who underwent radical or partial laparoscopic nephrectomy. The main factor of interest in this study was the fasting glucose level 2 days prior (or the nearest point in time) to surgery. The researchers performed logistic regression analyses to evaluate patterns involving POBG level and hospital LOS of more than 2 weeks or more than 3 weeks.

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A total of 338 patients were included in the study. Patients were categorized into 3 groups based on POBG level using the following thresholds: <4.94 mmol/L, 4.94 to <7.11 mmol/L, and ≥7.11 mmol/L. The lowest-threshold group had 112 patients, and the intermediate- and highest-threshold groups each had 113 patients.

The adjusted risk for LOS more than 2 weeks and more than 3 weeks showed a gradual increase with higher POBG levels. Patients in the highest threshold group showed a 115% greater risk of hospitalization for more than 2 weeks than did patients in the lowest threshold group. The adjusted odds risk (aOR) for this comparison was 2.15 (95% CI, 1.11-4.20; P =.024). The aOR for an LOS of more than 3 weeks was 2.29 (95% CI, 1.16-4.52; P =.017) for patients in the highest threshold group compared with the lowest threshold group, equal to an increased risk of 129% for patients with the highest vs the lowest POBG levels.

“In summary, we found that higher POBG levels were significantly associated with prolonged LOS in patients with RCC undergoing laparoscopic nephrectomy,” the researchers wrote in their report.


He T, Zhu W, Wang C, et al. Relationship between pre-operative blood glucose level and length of hospital stay in patients with renal cell carcinoma undergoing laparoscopic nephrectomy. Front Surg. 2021;8:659365. doi:10.3389/fsurg.2021.659365