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Cancer Management and Research

A Prospective Study on Urine Alkalization With an Oral Regimen Consisting of Sodium Bicarbonate and Acetazolamide in Patients Receiving High-dose Methotrexate

[Cancer Management and Research] Researchers sought an alternative regimen for urine alkalization in patients receiving high-dose methotrexate. The typical regimen, IV sodium bicarbonate, has been on shortage. This study determined the safety of an oral regimen of sodium bicarbonate and acetazolamide to achieve a urine pH >7, which is necessary for safe administration of high-dose methotrexate.
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