LEAP-005 investigators tested the safety and efficacy of combination lenvatinib and pembrolizumab in 32 patients with previously treated advanced non–microsatellite instability-high (MSI-H)/mismatch repair proficient (pMMR) colorectal cancer (CRC).
Investigators reviewed data from 202,237 patients from the Surveillance, Epidemiology, and End Results (SEER) registry who had been diagnosed CRC with 2010 and 2015.
Using data from the Minnesota Colon Cancer Control Study, a team of investigators assessed the impact of polypectomy on the incidence of colorectal cancer.
Investigators found a high prevalence of clinically relevant colorectal diseases and cancer among patients undergoing colonoscopy when quality parameters were emphasized.
The “watch and wait” approach is characterized by close surveillance without surgery in patients with rectal cancer who achieve a clinical CR following neoadjuvant CRT.