Cervical adenocarcinoma (ADC) was less likely to be diagnosed in Black women but its mortality rate was higher among these patients, compared with White women. These findings were published in the Journal of Clinical Oncology.
In the United States, incidence of cervical cancer has been declining in recent years overall, but incidence of cervical ADC has been increasing. Some evidence suggests that trends in cervical cancer are related to ethnicity. In this study, sociodemographic-related trends in cervical cancer incidence and mortality between 2000 and 2018 were evaluated using data from SEER21 and SEER18 databases.
A total of 75,422 cases of cervical cancer were included in this study. Incidence rates were higher in Black (adjusted incidence rate ratio [aIRR], 1.7), Hispanic (aIRR, 1.6), and American Indian or Alaska Native (AI/AN; aIRR, 1.2) women compared with White women.
Compared with White women, incidence rates for squamous cell carcinoma (SCC), adenosquamous carcinoma (ADSC), and ADC varied: in Black women, SCC and ADSC were higher (aIRR, 2.0 and 1.4, respectively) and ADC was lower (aIRR, 0.8); in Hispanic women, SCC, ADSC, and ADC were higher (aIRR, 1.7, 1.7, and 1.2, respectively); in AI/AN women, SCC was higher (aIRR, 1.3); and in Asian or Pacific Islander (API) women, ADC was lower (aIRR, 0.8).
Overall, mortality occurred in 10,488 cases of cervical cancer. Mortality rates were higher in Black, AI/AN, and Hispanic women compared with White women (adjusted mortality rate ratio [aMRR], 1.9, 1.5, and 1.4, respectively).
Subtype-specific mortality rates were elevated in Black women with SCC, ADC, and ADSC (aMRR, 2.1, 1.4, and 1.4, respectively); in AI/AN women with SCC (aMRR, 1.5); and in Hispanic women with SCC and ADSC (aMRR, 1.4 and 1.3, respectively), compared with White women.
These data indicated that compared with White women, Black women had a higher mortality rate from cervical ADC despite a lower incidence rate.
Disclosure: Multiple authors declared affiliations with biotech, pharmaceutical, and/or device companies. Please see the original reference for a full list of disclosures.
Cohen CM, Wentzensen N, Castle PE, et al. Racial and ethnic disparities in cervical cancer incidence, survival, and mortality by histologic subtype. J Clin Oncol. 2023;41(5):1059-1068. doi:10.1200/JCO.22.01424