The American Society of Clinical Oncology (ASCO) for the first time is recommending global guidance for human papillomavirus (HPV) vaccination for cervical cancer prevention. ASCO is issuing specific recommendations that can be adapted to different resource levels.1

The guideline includes specific recommendations based on 4 levels of resource settings: basic, limited, enhanced, and maximal. ASCO recommendations for all environments, and independent of the resource settings, are 2 doses of HPV vaccine for girls ages 9 to 14 years, with an interval of at least 6 months and up to 12 to 15 months between doses. The guideline calls for 3 doses for girls who are HIV positive.

This is the first guideline on primary prevention of cervical cancer that is tailored to multiple regions of the world with different levels of socio-economic and structural resource settings using evidence-based guidance, according to a news release from ASCO.2

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For maximal and enhanced resource settings, girls aged 15 years or older who received their first dose before that age may complete the 2-dose series. Those girls who have not received their first dose before age 15 years, they should receive 3 doses. In both scenarios, vaccination may be given through age 26 years.

In limited and basic resource settings, if sufficient resources remain after vaccinating girls 9 to 14 years, girls who received 1 dose may receive additional doses between ages 15 and 26 years. Boys may be vaccinated if there is at least 50% coverage of the priority female target population, sufficient resources, and such vaccination is cost effective.


1. Arrossi S, Temin S, Garland S, et al. The primary prevention of cervical cancer: American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline. J Glob Oncol. 2017 Mar 17. doi: 10.1200/JGO.2016.008151 [Epub ahead of print]

2. First global guidance for HPV vaccination for cervical cancer prevention. Alexandria, VA: American Society of Clinical Oncology; March 17, 2017. EurekAlert! website. Accessed April 4, 2017.