A Systematic Review and Meta-analysis of Harmonic Technology Compared With Conventional Techniques in Mastectomy and Breast-conserving Surgery With Lymphadenectomy for Breast Cancer

Intraoperative blood loss

Mean intraoperative blood loss (Harmonic technology: 145.37 mL, conventional technique: 232.90 mL) was statistically significantly reduced by 87.54 mL (95% CI: −137.07 to −38.02; P=0.0005; eight studies; I²=99%), a 37.59% decrease with Harmonic technology compared to conventional methods in breast surgery (Figure 3; Table 3). Reductions in intraoperative blood loss were similar across study subgroups, with the greatest reduction reported in studies conducting mastectomies (with lymph node dissection) only.