Our meta-analysis suggested that EGFR may serve as a useful biomarker for poor prognosis in glioma patients. In the future, targeted therapy aiming at EGFR signaling pathways may help slow the disease progression of glioma and prolong OS. To verify this result, studies with large sample sizes, covering extensive areas, with more reasonable experimental designs, more standardized diagnostic criteria, and standardized postoperative treatment are required.


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This study was supported by the Key Research and Development Item from the Department of Science and Technology of Sichuan Province, China (No 2017SZ0006). Junhong Li and Ruofei Liang are the co-first authors.


The authors report no conflicts of interest in this work.


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