Some Targeted Therapies May Miss the Mark
Ten different drugs continued to kill cancer cells even when their target proteins were removed.
Brain Cancer
Brain Cancer News & Features
Ribociclib Shown to Penetrate the Blood-Brain Barrier in Glioblastoma
A phase 0 study of ribociclib in patients with recurrent glioblastoma seeks to inform the feasibility of the use of CDK 4/6 inhibitors for deadly brain tumors.
Enhanced Reimbursement Incentives for Generic Cancer Drugs Found Not to Affect Prescribing Patterns
Critics of the study say they are not surprised by the study’s conclusions, as oncologists make treatment decisions based on best treatment course, not money.
Combining CAR-T and BiTE in Models of Glioblastoma Multiforme
This study involved the engineering of CAR-T cells specific for the EGFRvIII antigen to also secrete bispecific T cell engagers (BiTEs) against wild-type EGFR.
Clinician Interaction Scored High, Some Discussion Topics Did Not in Patient Assessment of Quality of Care
In a survey of patients’ perceptions, doctor/nurse interactions were rated high; however, some specific topics for discussion were not rated as high.
Brain Cancer Clinical Trials
Differences in Postrelapse Mortality May be Driving Racial/Ethnic Disparities Observed in Children With Hodgkin Lymphoma
No difference in event-free survival (EFS) was observed in children and adolescents with newly diagnosed Hodgkin lymphoma (HL) according to race/ethnicity; however, postrelapse mortality was found to be higher in nonwhite groups. The findings from this pooled, secondary analysis of data from phase 3 clinical trials of dose-dense, response-adapted therapy were published in the Journal…
Use of PRO-CTCAE May Help Identify Underreported Adverse Effects in Phase 1 Clinical Trials
Agreement between patient- and physician-reported adverse effects during phase 1 clinical trials varies from poor to fair.
Complementary Medicine Use Is Common Among Participants in Phase 3 Clinical Trials
Researchers identify trends in use of complementary medicine among patients with breast, colorectal, or lung cancer while participating in phase 3 clinical trials.
Clinical Trial Participation May Not Improve Outcomes in Socioeconomically Deprived Areas
Researchers demonstrated the significance of access to supportive and posttrial care as it relates to cancer survival among clinical trial participants.
FDA: Men Should Be Included in Breast Cancer Clinical Trials
Draft guidance that men be included in breast cancer trials issued by the FDA.
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